| Author | Adamoski, Douglas | |
| Author | Baura, Valter Antonio de | |
| Author | Rodrigues, Ana Carolina | |
| Author | Royer, Carla Adriane | |
| Author | Aoki, Mateus Nóbrega | |
| Author | Tschá, Marcel Kruchelski | |
| Author | Bonatto, Ana Claudia | |
| Author | Wassem, Roseli | |
| Author | Nogueira, Meri Bordignon | |
| Author | Raboni, Sonia Mara | |
| Author | Almeida, Bernardo Montesanti Machado de | |
| Author | Trindade, Edvaldo da Silva | |
| Author | Gradia, Daniela Fiori | |
| Author | Souza, Emanuel Maltempi | |
| Author | Oliveira, Jaqueline Carvalho de | |
| Access date | 2022-05-25T17:52:57Z | |
| Available date | 2022-05-25T17:52:57Z | |
| Document date | 2022 | |
| Citation | ADAMOSKI, Douglas et al. SARS-CoV-2 Delta and Omicron variants surge in Curitiba, southern Brazil, and its impact on overall COVID-19 lethality. Viruses, V. 14, n. 809 p. 1–8, 2022. | pt_BR |
| ISSN | 1999-4915 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/52879 | |
| Language | por | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | SARS-CoV-2 | pt_BR |
| Subject in Portuguese | Coronavirus | pt_BR |
| Subject in Portuguese | Omicron | pt_BR |
| Subject in Portuguese | Delta | pt_BR |
| Subject in Portuguese | Taxa de Letalidade | pt_BR |
| Subject in Portuguese | Paraná | pt_BR |
| Title | SARS-CoV-2 Delta and Omicron variants surge in Curitiba, southern Brazil, and its impact on overall COVID-19 lethality | pt_BR |
| Type | Article | pt_BR |
| DOI | https://doi.org/10.3390/v14040809 | |
| Abstract | Screening efforts and genomic surveillance are essential tools to evaluate the course of the COVID-19 pandemic and assist the public healthcare system in dealing with an increasing number of infections. For the analysis of COVID-19 cases scenarios in Curitiba, Paraná, Brazil, we performed a diagnosis of positive cases, coupled with genotyping, for symptomatic and asymptomatic members of the Federal University of Paraná. We achieved over 1000 samples using RT-qPCR for diagnosis. The posterior genotyping allowed us to observe differences in the spread of strains in Curitiba, Brazil. The Delta variant was not associated with an infection wave, whereas the rapid Omicron variant spread became dominant in less than one month. We also evaluated the general vaccination coverage in the state, observing a striking reduction in lethality correlated to the vaccinated fraction of the population; although lower lethality rates were not much affected by the Omicron variant wave, the same effect was not translated in the number of infections. In summary, our results provide a general overview of the pandemic’s course in Paraná State and how there was reduction in lethality after a combination of multiple infection waves and a large-scale vaccination program. | pt_BR |
| Affilliation | Centro Nacional de Pesquisa em Energia e Materiais. Laboratório Nacional de Biociências. Campinas, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Complexo Hospital de Clínicas. Laboratório de Virologia. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Complexo Hospital de Clínicas. Laboratório de Virologia. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | HiLab Laboratório. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Biologia Celular. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil. | pt_BR |
| Subject | Public Health | pt_BR |
| Subject | Diagnosis | pt_BR |
| Subject | Vaccination | pt_BR |
| Subject | Genotyping Techniques | pt_BR |
| Subject | Reverse Transcriptase Polymerase Chain Reaction | pt_BR |
| Subject | lethality | pt_BR |
| Subject in Spanish | Salud Pública | pt_BR |
| Subject in Spanish | Vacunación | pt_BR |
| Subject in Spanish | Técnicas de Genotipaje | pt_BR |
| Subject in Spanish | Reacción en Cadena de la Polimerasa de Transcriptasa Inversa | pt_BR |
| Subject in Spanish | Mortalidad | pt_BR |
| Subject in French | Santé publique | pt_BR |
| Subject in French | Diagnostic | pt_BR |
| Subject in French | Vaccination | pt_BR |
| Subject in French | Techniques de génotypage | pt_BR |
| Subject in French | RT-PCR | pt_BR |
| Subject in French | Mortalité | pt_BR |
| DeCS | Saúde Pública | pt_BR |
| DeCS | Diagnóstico | pt_BR |
| DeCS | Vacinação | pt_BR |
| DeCS | Técnicas de Genotipagem | pt_BR |
| DeCS | Reação em Cadeia da Polimerase Via Transcriptase Reversa | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
