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SARS-COV-2 DELTA AND OMICRON VARIANTS SURGE IN CURITIBA, SOUTHERN BRAZIL, AND ITS IMPACT ON OVERALL COVID-19 LETHALITY
Adamoski, Douglas et al. | Date Issued: 2022
Author
Adamoski, Douglas
Baura, Valter Antonio de
Rodrigues, Ana Carolina
Royer, Carla Adriane
Aoki, Mateus Nóbrega
Tschá, Marcel Kruchelski
Bonatto, Ana Claudia
Wassem, Roseli
Nogueira, Meri Bordignon
Raboni, Sonia Mara
Almeida, Bernardo Montesanti Machado de
Trindade, Edvaldo da Silva
Gradia, Daniela Fiori
Souza, Emanuel Maltempi
Oliveira, Jaqueline Carvalho de
Affilliation
Centro Nacional de Pesquisa em Energia e Materiais. Laboratório Nacional de Biociências. Campinas, SP, Brasil.
Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Complexo Hospital de Clínicas. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Complexo Hospital de Clínicas. Laboratório de Virologia. Curitiba, PR, Brasil.
HiLab Laboratório. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Departamento de Biologia Celular. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.
Abstract
Screening efforts and genomic surveillance are essential tools to evaluate the course of the COVID-19 pandemic and assist the public healthcare system in dealing with an increasing number of infections. For the analysis of COVID-19 cases scenarios in Curitiba, Paraná, Brazil, we performed a diagnosis of positive cases, coupled with genotyping, for symptomatic and asymptomatic members of the Federal University of Paraná. We achieved over 1000 samples using RT-qPCR for diagnosis. The posterior genotyping allowed us to observe differences in the spread of strains in Curitiba, Brazil. The Delta variant was not associated with an infection wave, whereas the rapid Omicron variant spread became dominant in less than one month. We also evaluated the general vaccination coverage in the state, observing a striking reduction in lethality correlated to the vaccinated fraction of the population; although lower lethality rates were not much affected by the Omicron variant wave, the same effect was not translated in the number of infections. In summary, our results provide a general overview of the pandemic’s course in Paraná State and how there was reduction in lethality after a combination of multiple infection waves and a large-scale vaccination program.
Keywords in Portuguese
SARS-CoV-2
Coronavirus
Omicron
Delta
Taxa de Letalidade
Paraná
 
Keywords
Public Health
Diagnosis
Vaccination
Genotyping Techniques
Reverse Transcriptase Polymerase Chain Reaction
lethality
 
Keywords in Spanish
Salud Pública
Vacunación
Técnicas de Genotipaje
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
Mortalidad
 
DeCS
Saúde Pública
Diagnóstico
Vacinação
Técnicas de Genotipagem
Reação em Cadeia da Polimerase Via Transcriptase Reversa
 
Publisher
MDPI
Citation
ADAMOSKI, Douglas et al. SARS-CoV-2 Delta and Omicron variants surge in Curitiba, southern Brazil, and its impact on overall COVID-19 lethality. Viruses, V. 14, n. 809 p. 1–8, 2022.
DOI
https://doi.org/10.3390/v14040809
ISSN
1999-4915