| Author | Prata, Rhana Berto da Silva | |
| Author | Mendes, Mayara Abud | |
| Author | Soares, Vinicius Cardoso | |
| Author | Costa, Jaqueline França | |
| Author | Sales, Anna Maria | |
| Author | Duppre, Nádia Cristina | |
| Author | Borges, Valeria de Matos | |
| Author | Silva, Tatiana Pereira da | |
| Author | Bozza, Patrícia T. | |
| Author | Bozza, Marcelo Torres | |
| Author | Sarno, Euzenir Nunes | |
| Author | Moraes, Milton Ozório | |
| Author | Silva, Gilberto Marcelo Sperandio da | |
| Author | Pinheiro, Roberta Olmo | |
| Access date | 2022-06-20T12:26:14Z | |
| Available date | 2022-06-20T12:26:14Z | |
| Document date | 2022 | |
| Citation | PRATA, Rhana Berto da Silva et al. Arginase 1 is a marker of protection against illness in contacts of leprosy patients. Scientific Reports, v. 12, n. 7850, p. 1-9, 12 May 2022. | |
| ISSN | 2045-2322 | |
| URI | https://www.arca.fiocruz.br/handle/icict/53364 | |
| Description | Produção científica do Laboratório de Hanseníase. | pt_BR |
| Description | Produção científica do Laboratório de Imunofarmacologia. | pt_BR |
| Sponsorship | We also thank the Coordination for the Improvement of Higher Education Personnel (CAPES). | |
| Sponsorship | Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ). | |
| Sponsorship | National Council for Scientific and Technological Development (CNPq) for funding. | |
| Language | eng | en_US |
| Publisher | Nature Research | |
| Rights | open access | |
| Subject in Portuguese | Arginase 1 | pt_BR |
| Subject in Portuguese | Marcador | pt_BR |
| Subject in Portuguese | Proteção contra doenças | pt_BR |
| Subject in Portuguese | Pacientes leprosos | pt_BR |
| Title | Arginase 1 is a marker of protection against illness in contacts of leprosy patients | en_US |
| Type | Article | |
| DOI | 10.1038/s41598-022-11944-9 | |
| Abstract | Leprosy household contacts are generally more prone to develop the disease compared to the general population. Previous studies have demonstrated that genes related to the alternative activation (M2) profile in macrophages are associated with the increased bacillary load in multibacillary leprosy patients (MB), and that contacts of MB patients have a higher risk of contracting the disease. In addition, positive serological responses to PGL-1 or LID-1 are associated with a higher risk of disease. We performed a 5-year follow-up of contacts of leprosy patients and evaluated the pattern of gene and protein expression in cells from contacts that developed leprosy during this period. Leprosy household contacts had decreased soluble CD163 and heme oxygenase 1 (HO-1) serum levels when compared with healthy donors and leprosy patients. In contrast, arginase 1 activities were higher in contacts when compared with both healthy donors and leprosy patients. Of the contacts, 33 developed leprosy during the follow-up. Gene expression analysis revealed reduced ARG1 expression in these contacts when compared with contacts that did not develop disease. Arginase activity was a good predictive marker of protection in contacts (sensitivity: 90.0%, specificity: 96.77%) and the association with serology for anti-PGL-1 and anti-LID-1 increased the sensitivity to 100%. Altogether, the data presented here demonstrate a positive role of arginase against leprosy and suggest that the evaluation of arginase activity should be incorporated into leprosy control programs in order to aid in the decision of which contacts should receive chemoprophylaxis. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Paulo de Góes. Laboratório de Inflamação e Imunidade. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Edgar Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Paulo de Góes. Laboratório de Inflamação e Imunidade. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil | |
| Subject | Arginase 1 | en_US |
| Subject | Marker of protection | en_US |
| Subject | Against Illness | en_US |
| Subject | Leprosy patients | en_US |
| e-ISSN | 2045-2322 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
