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IMMUNE RESPONSES IN LEISHMANIASIS: AN OVERVIEW
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Abstract
Leishmaniasis is a parasitic, widespread, and neglected disease that affects more than
90 countries in the world. More than 20 Leishmania species cause different forms of leishmaniasis
that range in severity from cutaneous lesions to systemic infection. The diversity of leishmaniasis
forms is due to the species of parasite, vector, environmental and social factors, genetic background,
nutritional status, as well as immunocompetence of the host. Here, we discuss the role of the
immune system, its molecules, and responses in the establishment, development, and outcome of
Leishmaniasis, focusing on innate immune cells and Leishmania major interactions.
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