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Sustainable Development Goals
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- IOC - Artigos de Periódicos [12978]
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SYSTEMIC RESPONSE TO INFECTION INDUCES LONG-TERM COGNITIVE DECLINE: NEUROINFLAMMATION AND OXIDATIVE STRESS AS THERAPEUTICAL TARGETS
Neuroinflamação
Estresse oxidativo
Deficiência cognitiva
Terapia aditiva
Neuroinflammation
Oxidative stress
Cognitive impairment
Additive therapy
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Abstract
In response to pathogens or damage signs, the immune system is activated in order
to eliminate the noxious stimuli. The inflammatory response to infectious diseases
induces systemic events, including cytokine storm phenomenon, vascular dysfunction,
and coagulopathy, that can lead to multiple-organ dysfunction. The central nervous
system (CNS) is one of the major organs affected, and symptoms such as sickness
behavior (depression and fever, among others), or even delirium, can be observed due
to activation of endothelial and glial cells, leading to neuroinflammation. Several reports
have been shown that, due to CNS alterations caused by neuroinflammation, some
sequels can be developed in special cognitive decline. There is still no any treatment
to avoid cognitive impairment, especially those developed due to systemic infectious
diseases, but preclinical and clinical trials have pointed out controlling neuroinflammatory
events to avoid the development of this sequel. In this minireview, we point to the
possible mechanisms that triggers long-term cognitive decline, proposing the acute
neuroinflammatory events as a potential therapeutical target to treat this sequel that
has been associated to several infectious diseases, such as malaria, sepsis, and, more
recently, the new SARS-Cov2 infection.
Keywords in Portuguese
Doenças infecciosasNeuroinflamação
Estresse oxidativo
Deficiência cognitiva
Terapia aditiva
Keywords
Infectious diseasesNeuroinflammation
Oxidative stress
Cognitive impairment
Additive therapy
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