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DESTRUCTION OF SCHISTOSOMA MANSONI SPOROCYSTS IN BIOMPHALARIA GLABRATA AFTER PHYTOCHEMICAL EXPOSURE
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Abstract
Schistosomiasis is a neglected tropical disease and affects over 200 million
people worldwide. The snail Biomphalaria glabrata is one of the intermediate hosts of
S. mansoni. The aim of this work was to verify the action of Euphorbia milii var. hislopii
latex in the hemocytes profile and histopathology of B. glabrata infected by S. mansoni.
Uninfected and infected snails were exposed to sublethal concentration of E. milii latex
for 24 hours (1.0 mg/L). The survival rate was 88.5% for the uninfected snails and 66.6%
for the infected and exposed snails. In the snails infected by S. mansoni, the exposure
to E. milii latex promoted proliferation of hemocytes in the tentacles, mantle, digestive
gland and kidney. In the digestive gland and the kidney, granulomatous reactions
occurred around the sporocysts and caused their destruction. The number of circulating
hemocytes from the group infected and exposed to E. milii latex was significantly higher
than in the other groups. Three types of hemocytes were found: hyalinocytes, granulocytes
and blast-like cells. We conclude that the E. milii latex influenced the cellular immune
response of the susceptible B. glabrata strain to infection by S. mansoni, promoting the
destruction of parasites.
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