| Autor | Nascimento, Lilian Gonçalves do | |
| Autor | Fialho, Alexandre Madi | |
| Autor | Andrade, Juliana da Silva Ribeiro de | |
| Autor | Assis, Rosane Maria Santos de | |
| Autor | Fumian, Tulio Machado | |
| Data de acesso | 2022-07-31T13:28:08Z | |
| Data de disponibilização | 2022-07-31T13:28:08Z | |
| Data do publicação | 2022 | |
| Citação | NASCIMENTO, Lilian Gonçalves do et al. Human enteric adenovirus F40/41 as a major cause of acute gastroenteritis in children in Brazil, 2018 to 2020. Scientific Reports, v. 12, 11220, p. 1 - 12, 2022. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/54091 | |
| Idioma | eng | pt_BR |
| Editor | Nature Portfolio | pt_BR |
| Direito Autoral | open access | |
| Palavras-chave | Adenovírus entérico humano F40/41 | pt_BR |
| Palavras-chave | Maior causa de aguda Gastroenterite | pt_BR |
| Palavras-chave | Crianças | pt_BR |
| Palavras-chave | De 2018 - 2020 | pt_BR |
| Palavras-chave | Brasil | pt_BR |
| Título | Human enteric adenovirus F40/41 as a major cause of acute gastroenteritis in children in Brazil, 2018 to 2020 | pt_BR |
| Tipo do documento | Article | |
| DOI | 10.1038/s41598-022-15413-1 | |
| Resumo em Inglês | Human adenovirus (HAdV) types F40/41 have long been recognized as major viral agents of acute
gastroenteritis (AGE) in children. Despite this, studies on HAdV molecular epidemiology are sparse,
and their real impact is likely under-estimated. Thus, our goal was to investigate HAdV incidence,
enteric and non-enteric types circulation, co-detections with rotavirus and norovirus and DNA
shedding in stool samples from inpatients and outpatients from eleven Brazilian states. During the
three-year study, 1012 AGE stool samples were analysed by TaqMan-based qPCR, to detect and
quantify HAdV. Positive samples were genotyped by partial sequencing of the hexon gene followed
by phylogenetic analysis. Co-detections were accessed by screening for rotavirus and norovirus.
Overall, we detected HAdV in 24.5% of single-detected samples (n = 248), with a prevalence of
type F41 (35.8%). We observed a higher incidence in children between 6 to 24 months, without
marked seasonality. Additionally, we observed a statistically higher median viral load among singledetections
between enteric and non-enteric types and a significantly lower HAdV viral load compared
to rotavirus and norovirus in co-detections (p < 0.0001). Our study contributes to the knowledge of
HAdV epidemiology and reinforces the need for the inclusion of enteric types F40/41 in molecular
surveillance programs. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Palavras-chave em inglês | Adenovírus entérico humano F40/41 | pt_BR |
| Palavras-chave em inglês | Major cause | pt_BR |
| Palavras-chave em inglês | Acute gastroenteritis | pt_BR |
| Palavras-chave em inglês | Children | pt_BR |
| Palavras-chave em inglês | Brazil, 2018 to 2020 | pt_BR |
