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HUMAN ENTERIC ADENOVIRUS F40/41 AS A MAJOR CAUSE OF ACUTE GASTROENTERITIS IN CHILDREN IN BRAZIL, 2018 TO 2020
Maior causa de aguda Gastroenterite
Crianças
De 2018 - 2020
Brasil
Major cause
Acute gastroenteritis
Children
Brazil, 2018 to 2020
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
Abstract
Human adenovirus (HAdV) types F40/41 have long been recognized as major viral agents of acute
gastroenteritis (AGE) in children. Despite this, studies on HAdV molecular epidemiology are sparse,
and their real impact is likely under-estimated. Thus, our goal was to investigate HAdV incidence,
enteric and non-enteric types circulation, co-detections with rotavirus and norovirus and DNA
shedding in stool samples from inpatients and outpatients from eleven Brazilian states. During the
three-year study, 1012 AGE stool samples were analysed by TaqMan-based qPCR, to detect and
quantify HAdV. Positive samples were genotyped by partial sequencing of the hexon gene followed
by phylogenetic analysis. Co-detections were accessed by screening for rotavirus and norovirus.
Overall, we detected HAdV in 24.5% of single-detected samples (n = 248), with a prevalence of
type F41 (35.8%). We observed a higher incidence in children between 6 to 24 months, without
marked seasonality. Additionally, we observed a statistically higher median viral load among singledetections
between enteric and non-enteric types and a significantly lower HAdV viral load compared
to rotavirus and norovirus in co-detections (p < 0.0001). Our study contributes to the knowledge of
HAdV epidemiology and reinforces the need for the inclusion of enteric types F40/41 in molecular
surveillance programs.
Keywords in Portuguese
Adenovírus entérico humano F40/41Maior causa de aguda Gastroenterite
Crianças
De 2018 - 2020
Brasil
Keywords
Adenovírus entérico humano F40/41Major cause
Acute gastroenteritis
Children
Brazil, 2018 to 2020
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