Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/54473
Title: Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni
Authors: Pereira, Neusa Araújo
Mattos, Ana Carolina Alves de
Sarvel, Ana Karine
Coelho, Paulo Marcos Zech
Katz, Naftale
Affilliation: Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil/ Santa Casa de Misericórdia de Belo Horizonte. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil/ Santa Casa de Misericórdia de Belo Horizonte. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil/ Santa Casa de Misericórdia de Belo Horizonte. Belo Horizonte, MG, Brazil
Abstract: The activity of lovastatin associated with oxamniquine or praziquantel against schistosomiasis mansoni was evaluated in mice infected with Schistosoma mansoni. Forty days after infection, mice were treated with lovastatin, 400 mg/kg for five consecutive days by oral route, and on the last day of this sequence with 50 mg/kg oxamniquine or with 200 mg/kg praziquantel, both by oral route, single dose. Fifteen days later, the animals were perfused in parallel with an untreated control group. Studies were carried out in vitro, using lovastatin in culture medium containing S. mansoni worms proceeding from experimentally infected mice. In the in vivo trials, the association of lovastatin with oxamniquine or praziquantel did not show any additive action, but there were oogram changes when lovastatin was associated with oxamniquine. In vitro lovastatin was able to interrupt the maturation of S. mansoni eggs, which remained at the 1st or 2nd stages, depending on the dose used. The total number of morphologically dead eggs found in culture of worms exposed to 2 mu g/ml or 4 mu g/ml concentrations of lovastatin was significantly higher than the number of viable eggs. Using the probe Hoescht 33258 it was observed that 70% of the eggs considered morphologically viable in the treated groups (against 16% in the control group) were labeled, indicating that the majority of the viable eggs had membrane permeability increased due to lovastatin action
Keywords: Schistosoma mansoni
lovastatin
drug association
Issue Date: 2008
Publisher: Instituto Oswaldo Cruz
Citation: ARAÚJO, Neusa Pereira et al. Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni. Mem. Inst. Oswaldo Cruz, v. 103, n. 5, p. 450-454, 2008. doi.org/10.1590/S0074-02762008000500007
DOI: 10.1590/S0074-02762008000500007
ISSN: 0074-0276
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos
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