Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5499
Title: Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens.
Authors: Pontes-de-Carvalho, Lain Carlos
Santana, Cláudia Dias de
Soares, Milena Botelho Pereira
Oliveira, Geraldo Gileno de Sá
Cunha Neto, Edecio
Santos, Ricardo Ribeiro dos
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
University of São Paulo Medical School. Heart Institute InCor and Division of Clinical Immunology and Allergy. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: The protozoan Trypanosoma cruzi causes chronic Chagas’ disease myocarditis (CCDM) in infected mammals. The pathogenesis of CCDM, however, is still unclear. Indirect evidence for either parasite- or heart-specific immune responses playing a pathogenic role is available. In this work, the participation of autoimmunity in the development of CCDM is demonstrated in mice in which immunological tolerance to heart antigens was induced or strengthened prior to their infection by T. cruzi. Tolerance was induced by heart antigen administration in the presence of complete Freund’s adjuvant and anti-CD4 antibodies. Tolerized mice developed less intense CCDM than control nontolerized animals that had received only anti-CD4 and adjuvant. This result confirms the important notion that tolerance to self, and in particular to heart antigens, may be reinforced/induced in normal animals, and raises the possibility that analogous interventions may prevent the development of CCDM in millions of T. cruzi-infected human beings.
Keywords: Anti-CD4
Experimental autoimmune myocarditis
Chagas’ disease
Trypanosoma cruzi
Immunological tolerance
DeCS: Doenças Auto-Imunes/imunologia
Doenças Auto-Imunes/prevenção & controle
Cardiomiopatia Chagásica/imunologia
Cardiomiopatia Chagásica/prevenção & controle
Anticorpos Monoclonais/farmacologia
Antígenos CD4/imunologia
Auto-Antígenos/administração & dosagem
Tolerância Imunológica
Animais
Feminino
Humanos
Imunossupressão
Camundongos
Camundongos Endogâmicos BALB C
Miocárdio/imunologia
Miosinas/administração & dosagem
Miosinas/imunologia
Trypanosoma cruzi/patogenicidade
Issue Date: 2002
Citation: PONTES-DE-CARVALHO, L. et al. Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens. Journal of Autoimmunity, v. 18, n. 2, p. 131-8, mar. 2002.
DOI: 10.1006/jaut.2001.0574, available online at http://www.idealibrary.com on
ISSN: 0896-8411
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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