Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5506
Title: Human retroviruses (HIV and HTLV) in Brazilian Indians: seroepidemiological study and molecular epidemiology of HTLV type 2 isolates.
Authors: Shindo, Nice
Alcantara, Luiz Carlos Júnior
Van Dooren, Sonia
Salemi, Marco
Costa, Maria Cristina Ramos
Kashima, Simone G
Covas, Dimas Tadeu
Teva, Antonio
Pellegrini, Marco
Brito, Ivo
Vandamme, Anne-Mieke
Castro Filho, Bernardo Galvão
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Catholic University of Leuven. Rega Institute. Leuven, Belgium
Catholic University of Leuven. Rega Institute. Leuven, Belgium
Blood Center of Ribeirão Preto. São Paulo, SP, Brasil
Blood Center of Ribeirão Preto. São Paulo, SP, Brasil
Blood Center of Ribeirão Preto. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
Brazilian Ministry of Health. CN-DST/AIDS. Brasilia, DF, Brasil
Brazilian Ministry of Health. CN-DST/AIDS. Brasilia, DF, Brasil
Catholic University of Leuven. Rega Institute. Leuven, Belgium
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: To investigate serological, epidemiological, and molecular aspects of HTLV-1, HTLV-2, and HIV-1 infections in Amerindian populations in Brazil, we tested 683 and 321 sera from Tiriyo and Waiampi Indians, respectively. Both HIV-1 and HTLV-2 infections were detected at low prevalence among the Tiriyos whereas only HTLV-1 was present among the Waiampis, also at low prevalence. Analysis of the nucleotide sequence of the 631 bp of the env gene obtained from the three HTLV-2 isolates detected among the Tiriyos demonstrated by restriction fragment length polymorphism that these viruses belong to subtype IIa. Phylogenetic analysis of this same fragment showed that these sequences cluster closer to HTLV-2 isolates from intravenous drug users living in urban areas of southern Brazil than to the same gene sequence studied in another Brazilian tribe, the Kayapos. Our results confirm the distribution of Brazilian HTLV-2 sequences in a unique cluster I and cluster IIa and suggest that there is a considerable degree of diversity within this cluster. We also report for the first time HIV-1 infection among Brazilian Amerindians.
DeCS: Anticorpos Antivirais/sangue
Infecções por HIV/virologia
HIV-1
Infecções por HTLV-I/virologia
Infecções por HTLV-II/virologia
Virus Linfotrópico de Células T Humanas Tipo 1
Vírus 2 Linfotrópico T Humano
Adolescente
Brasil/epidemiologia
Anticorpos Anti-HIV/sangue
Infecções por HIV/epidemiologia
HIV-1/imunologia
Infecções por HTLV-I/epidemiologia
Infecções por HTLV-II/epidemiologia
Virus Linfotrópico de Células T Humanas Tipo 1/imunologia
Vírus 2 Linfotrópico T Humano/genética
Vírus 2 Linfotrópico T Humano/imunologia
Vírus 2 Linfotrópico T Humano/isolamento & purificação
Índios Sul-Americanos
Epidemiologia Molecular
Dados de Sequência Molecular
RNA Viral/genética
Estudos Soroepidemiológicos
Prevalência
Issue Date: 2002
Citation: SHINDO, N. et al. Human retroviruses (HIV and HTLV) in Brazilian Indians: seroepidemiological study and molecular epidemiology of HTLV type 2 isolates. AIDS Research Human Retroviruses, v. 18, n. 1 p. 71-7, jan. 2002.
ISSN: 0889-2229
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
BA - IGM - Artigos de Periódicos

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