Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5508
Title: The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet.
Authors: Soares, Milena Botelho Pereira
Pontes-de-Carvalho, Lain Carlos
Santos, Ricardo Ribeiro dos
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Chagas' disease is a major health problem in Latin America, where it constitutes one of the leading causes of heart failure. About one fourth of Trypanosoma cruzi-infected individuals develop chronic chagasic cardiomyopathy (CChC), the most severe form of the disease. CChC is histologically characterized by the presence of multifocal inflammatory infiltrates in the heart, composed mainly by mononuclear cells, usually adhered to myocytes and leading to myocytolysis, and frequently by interstitial fibrosis. The pathogenesis of CChC is still unclear, despite intense investigations both in human beings and in animal models of the disease. Although tissue parasitism is rare in the chronic phase of infection, an immune response targeted to persistent parasites or parasite antigens is suggested, by some authors, as the pathogenic mechanism of CChC. Other researchers affirm that the lack of correlation between tissue parasitism and intensity of inflammation suggests, along with the presence of autoreactive immune responses, that CChC results from the action of an autoimmune response. Herein we review reports from the literature and our own data, which together indicate, on one hand, the participation of parasite-specific immune responses and, on the other hand, clearly demonstrate the participation of heart-specific immune responses in the pathogenesis of CChC. Moreover, multiple factors may determine whether an individual in the indeterminate form of the disease will develop CChC. The mechanisms by which T. cruzi breaks immunological tolerance to heart antigens are also discussed.
Keywords: Chagas’ disease
myocarditis,
Autoimmunity
Trypanosoma cruzi
Ddelayed-type hypersensitivity
DeCS: Auto-Imunidade
Cardiomiopatia Chagásica/imunologia
Trypanosoma cruzi/imunologia
Animais
Cardiomiopatia Chagásica/patologia
Doença Crônica
Humanos
Hipersensibilidade Tardia/imunologia
Tolerância Imunológica
Camundongos
Fatores de Tempo
Issue Date: 2001
Citation: SOARES, M.B.; PONTES-DE-CARVALHO, L.; RIBEIRO-DOS-SANTOS, R. The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet. Anais da Academia Brasileira de Ciencias, v. 73, n. 4, p. 547-59, dez. 2001.
ISSN: 0001-3765
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Soares MB The pathogenesis of Chagas' ....pdf661.36 kBAdobe PDFThumbnail
View/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.