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Title: Reporting on methods of subgroup analysis in clinical trials: a survey of four scientific journals.
Authors: Moreira Júnior, Edson Duarte
Stein, Z
Susser, Ezra
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Columbia University. Department of Psychiatry. New York, NY, United States of America
Columbia University. School of Public Health. Division of Epidemiology. New York, NY,United States of America
Abstract: Results of subgroup analysis (SA) reported in randomized clinical trials (RCT) cannot be adequately interpreted without information about the methods used in the study design and the data analysis. Our aim was to show how often inaccurate or incomplete reports occur. First, we selected eight methodological aspects of SA on the basis of their importance to a reader in determining the confidence that should be placed in the author’s conclusions regarding such analysis. Then, we reviewed the current practice of reporting these methodological aspects of SA in clinical trials in four leading journals, i.e., the New England Journal of Medicine, the Journal of the American Medical Association, the Lancet, and the American Journal of Public Health. Eight consecutive reports from each journal published after July 1, 1998 were included. Of the 32 trials surveyed, 17 (53%) had at least one SA. Overall, the proportion of RCT reporting a particular methodological aspect ranged from 23 to 94%. Information on whether the SA preceded/followed the analysis was reported in only 7 (41%) of the studies. Of the total possible number of items to be reported, NEJM, JAMA, Lancet and AJPH clearly mentioned 59, 67, 58 and 72%, respectively. We conclude that current reporting of SA in RCT is incomplete and inaccurate. The results of such SA may have harmful effects on treatment recommendations if accepted without judicious scrutiny. We recommend that editors improve the reporting of SA in RCT by giving authors a list of the important items to be reported.
Keywords: Subgroup analyses
Randomized clinical trials
Research design
Epidemiological methods
Effect modification
DeCS: Publicações Periódicas como Assunto/normas
Ensaios Clínicos Controlados Aleatórios como Assunto/normas
Interpretação Estatística de Dados
Ensaios Clínicos Controlados Aleatórios como Assunto/métodos
Projetos de Pesquisa/normas
Issue Date: 2001
Citation: MOREIRA, E. D.; STEIN, Z.; SUSSER, E. Reporting on methods of subgroup analysis in clinical trials: a survey of four scientific journals. Brazilian Journal of Medical Biological Research, v. 34, p. 11, p. 1441-6, Nov. 2001.
ISSN: 0100-879X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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