Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/55142

Type
Article
Copyright
Open access
Sustainable Development Goals
01 Erradicação da pobreza
05 Igualdade de gênero
10 Redução das desigualdades
 
Collections
Share

Statistics
Metadata
Show full item record

POSSIBLE SEX DIFFERENCE IN LATENT TUBERCULOSIS INFECTION RISK AMONG CLOSE TUBERCULOSIS CONTACTS
Wada, Paul Y et al. | Date Issued: 2022
Author
Wada, Paul Y
Costa, Allyson G
Pereira, Mariana Araújo
Duarte, Beatriz Barreto
Souza, Alexandra B
Rocha, Michael S
Figueiredo, Marina C
Turner, Megan M
Rolla, Valeria C
Kritski, Afrânio L
Santos, Marcelo Cordeiro
Andrade, Bruno B
Sterling, Timothy R
Rebeiro, Peter F
Affilliation
Division of Infectious Diseases. Department of Medicine. Vanderbilt University School of Medicine, Nashville, USA.
Universidade do Estado do Amazonas. Fundação Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.
Universidade do Estado do Amazonas. Fundação Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil.
Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil.
Vanderbilt Tuberculosis Center. Vanderbilt University School of Medicine. Nashville, USA.
Vanderbilt Tuberculosis Center. Vanderbilt University School of Medicine. Nashville, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacteriose. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.
Universidade do Estado do Amazonas. Fundação Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Universidade Nilton Lins. Faculdade de Medicina. Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Vanderbilt Tuberculosis Center. Vanderbilt University School of Medicine. Nashville, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacteriose. Rio de Janeiro, RJ, Brasil / Laureate Universities. Universidade Salvador. Curso de Medicina, Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Curso de Medicina. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Division of Infectious Diseases. Department of Medicine. Vanderbilt University School of Medicine, Nashville, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Vanderbilt Tuberculosis Center. Vanderbilt University School of Medicine. Nashville, USA.
Division of Infectious Diseases. Department of Medicine. Vanderbilt University School of Medicine, Nashville, USA / Department of Biostatistics. Vanderbilt University School of Medicine. Nashville, USA.
Abstract
Objectives: More men than women develop and die of tuberculosis (TB). Fewer data exist on sex differences in latent TB infection (LTBI). We assessed for potential sex differences in LTBI acquisition among close TB contacts. Methods: Regional Prospective Observational Research for TB-Brazil is an observational multi-center cohort of individuals with culture-confirmed pulmonary TB and their close contacts. Participants were enrolled from five sites in Brazil from June 2015 - June 2019. Close contacts were followed for 24 months after enrollment, with LTBI defined as a positive interferon-γ release assay (IGRA; QuantiFERON 3rd or 4th generation) at baseline or 6 months. We performed univariate, bivariate, and multivariable logistic regression and propensity-score weighted models to assess odds ratios (OR) and 95% confidence intervals (CI) for LTBI acquisition by birth sex among close contacts. Results: Of 1093, 504 (46%) female close contacts were IGRA positive compared to 295 of 745 (40%) men. The unadjusted OR for IGRA positivity among women vs men was 1.31 (95% CI: 1.08-1.58). Bivariate adjustments yielded ORs in women vs men ranging from 1.19 to 1.33 (P-value range: <0.01-0.07). Multivariable regression and weighted models yielded similar ORs in women vs men, of 1.14 (95% CI: 0.92-1.41) and 1.15 (95% CI: 0.94-1.40), respectively. Conclusion: The point estimate for LTBI among close TB contacts in Brazil was higher in women, though less pronounced in multivariable models. If the sex difference in LTBI is confirmed in additional settings, studies of possible underlying differences in socio-behavioral factors or TB pathogenesis are warranted.
Keywords in Portuguese
Tuberculose latente
Diferença de sexo
Ensaio de liberação de interferon-gama
Disparidades do estado de saúde
 
Keywords
Latent tuberculosis
Sex difference
Interferon-gamma release assay
Health status disparities
 
DeCS
Tuberculose Latente
Publisher
Elsevier
Citation
WADA, Paul Y. et al. Possible sex difference in latent tuberculosis infection risk among close tuberculosis contacts. International Journal of Infectious Diseases, v. 122, p. 1-8, 2022.
DOI
doi.org/10.1016/j.ijid.2022.07.031
ISSN
1201-9712