Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/552
Title: Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals
Authors: Bongertz, Vera
Reis, Elaine Priscilla Ouverney
Teixeira, Sylvia Lopes Maia
Jesus, Carlos Silva de
Hacker, Mariana de Andrea Vilas-Boas
Morgado, Mariza Gonçalves
Bastos, Francisco Inácio Pinkusfeld Monteiro
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Informação Científica e Tecnológica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Informação Científica e Tecnológica. Rio de Janeiro, RJ, Brasil.
Abstract: Sera from infected injection drug users (IDU) have shown to have antibodies against synthetic human immunodeficiency virus-1 (HIV-1) envelope peptides more frequently. In this study, reactivity of 48 IDU plasma were compared to 60 plasmas obtained from sexually infected individuals (S). The overall reactivity of plasma from IDU compared to S was higher, and the reactivity titers were much higher for IDU plasma than S. IDU plasma also showed a broader antibody response. The higher reactivity titers were observed mainly for the gp41 immunodominant epitope and V3 peptides corresponding to the consensus sequences of HIV-1 subtypes/variants prevalent in Brazil (B, F, C) indicating the specificity in the higher immune response of IDU.
Keywords: human immunodeficiency virus-1
Antibodies
injection drug users
Issue Date: 2003
Publisher: Fundação Oswaldo Cruz
Citation: BONGERTZ, V. et al. Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 2, p. 209-212, Mar. 2003.
ISSN: ISSN 0074-0276
Appears in Collections:ICICT - Artigos de Periódicos

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