Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5526
Title: Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
Authors: Gonçalves, Marilda de Souza
Queiroz, I. L
Cardoso, Silvia Andrade
Zanette, Angela Maria Dias
Strapazoni, A. C
Adorno, Elisângela Vitória
Albuquerque, Alessandra B. Lima
Sant'Ana, A
Reis, Mitermayer Galvão dos
Barral, Aldina Maria Prado
Barral Netto, Manoel
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Hemocentro da Bahia. Secretaria de Saúde do Estado da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Hemocentro da Bahia. Secretaria de Saúde do Estado da Bahia. Salvador, BA, Brasil
Fundação Hemocentro da Bahia. Secretaria de Saúde do Estado da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Hemocentro da Bahia. Secretaria de Saúde do Estado da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Sickle cell disease has a worldwide distribution and is a public health problem in Brazil. Although vaso-occlusive crisis (VOC) is one of the most important clinical features of the disease, there are still several steps of its pathogenesis which are unknown. The increase of the chemotactic factor interleukin 8 (IL-8) has been reported to be involved in sickle cell disease crisis, but this has not been demonstrated conclusively. In the present study we analyzed serum IL-8 levels by ELISA and hematological parameters and hemoglobin patterns by standard techniques in 23 (21 SS and 2 SC) Brazilian patients with sickle cell syndromes during VOC caused by different inducing factors, 22 (21 SS and 1 SC) sickle cell patients out of crisis, and 11 healthy controls. Increased IL-8 levels were observed in 19 of 23 VOC patients (79.2%), 3 of them with more than 1,000 pg/ml. Seventeen of 22 (77.3%) non-crisis patients showed low IL-8 levels (less than 15 pg/ml). Healthy controls had low IL-8 levels. A significant difference in serum IL-8 levels was observed between crisis and non-crisis sickle cell patients (P<0.0001). There was no correlation between IL-8 levels and hematological data or hemoglobin patterns. High serum IL-8 levels were observed in VOC patients independently of the crisis-inducing factor. We conclude that in the studied population, IL-8 concentration may be a useful VOC marker, although the mechanism of the pathogenic process of sickle cell VOC syndromes remains unclear.
Keywords: Interleukin 8
Sickle cell syndromes
Vaso-occlusive crisis
DeCS: Anemia Falciforme/sangue
Arteriopatias Oclusivas/sangue
Interleucina-8/sangue
Anemia Falciforme/fisiopatologia
Adolescente
Adulto
Arteriopatias Oclusivas/etiologia
Marcadores Biológicos/sangue
Brasil
Criança
Pré-Escolar
Feminino
Hemoglobina Falciforme/análise
Hemoglobinas/análise
Humanos
Lactente
Meia-Idade
Fatores de Risco
Sindrome
Issue Date: 2001
Citation: GONÇALVES, M.S. et al. Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease. Brazilian Journal of Medical and Biological Research, v. 34, n. 10, p. 1309-13, oct. 2001.
ISSN: 0100-879X
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
BA - IGM - Artigos de Periódicos

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