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FIRST REPORT OF LEISHMANIA RNA VIRUS 1 IN LEISHMANIA (VIANNIA) BRAZILIENSIS CLINICAL ISOLATES FROM RIO DE JANEIRO STATE - BRAZIL
Leishmania (Viannia) braziliensis
Isolados clínicos
Rio de Janeiro
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Abstract
BACKGROUND Leishmania parasites carry a double-stranded RNA virus (Leishmania RNA virus - LRV) that has been divided
in LRV1 and LRV2.
OBJECTIVES Leishmania (Viannia) braziliensis clinical isolates were assessed in order to determine LRV presence.
METHODS Two-round polymerase chain reaction (PCR and nested PCR) was performed to detect LRV1 or LRV2 in L. (V.)
braziliensis clinical isolates (n = 12).
FINDINGS LRV1 was detected in three clinical isolates which was phylogenetically related to other sequences reported from
other American tegumentary leishmaniasis (ATL) endemic areas of Brazil. Patients infected with L. (V.) braziliensis LRVnegative
showed only cutaneous lesions while LRV-positive reported different manifestations.
MAIN CONCLUSION Data presented here show for the first time that LRV1 is circulating in L. (V.) braziliensis clinical isolates
from Rio de Janeiro State in Brazil.
Keywords in Portuguese
Vírus RNA de Leishmania 1Leishmania (Viannia) braziliensis
Isolados clínicos
Rio de Janeiro
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