Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5629
Title: Hepatic capillariasis in rats: a new model for testing antifibrotic drugs.
Authors: Souza, Márcia Maria de
Silva, L. M.
Barbosa Junior, Aryon de Almeida
Oliveira, Irismar Reis de
Paraná, Raymundo
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, Bahia, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Abstract: Rats infected with the helminth Capillaria hepatica regularly develop septal hepatic fibrosis that may progress to cirrhosis in a relatively short time. Because of such characteristics, this experimental model was selected for testing drugs exhibiting antifibrosis potential, such as pentoxifylline, gadolinium chloride and vitamin A. Hepatic fibrosis was qualitatively and quantitatively evaluated in liver samples obtained by partial hepatectomy and at autopsy. The material was submitted to histological, biochemical and morphometric methods. A statistically significant reduction of fibrosis was obtained with pentoxifylline when administered intraperitoneally rather than intravenously. Gadolinium chloride showed moderate activity when administered prophylactically (before fibrosis had started), but showed a poor effect when fibrosis was well advanced. No modification of fibrosis was seen after vitamin A administration. Hydroxyproline content was correlated with morphometric measurements. The model appears to be adequate, since few animals die of the infection, fibrosis develops regularly in all animals, and the effects of different antifibrotic drugs and administration protocols can be easily detected.
Keywords: Capillaria hepatica
Hepatic fibrosis
Septal fibrosis
Antifibrotic drugs
Inibidores da Agregação de Plaquetas/uso
Vitamina A/uso terapêutico
DeCS: Infecções por Enoplida/quimioterapia
Gadolínio/uso terapêutico
Cirrose Hepática/quimioterapia
Pentoxifilina/uso terapêutico
Animais
Capillaria
Modelos Animais de Doenças
Feminino
Cirrose Hepática/parasitologia
Masculino
Ratos
Ratos Wistar
Fatores de Tempo
Issue Date: 2000
Citation: SOUZA, M.M. de et al. Hepatic capillariasis in rats: a new model for testing antifibrotic drugs. Brazilian Journal of Medical Biological Research, v. 33, n. 11, p. 1329-34, nov. 2000.
ISSN: 0100-879X
Appears in Collections:IGM - Artigos de Periódicos

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