Title:	Immunopathology of Chagas disease
Authors:	Andrade, Zilton de Araújo
Affilliation:	Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract:	The main clinical forms of Chagas disease (acute, indeterminate and chronic cardiac) present strong evidences for the participation of the immune system on pathogenesis. Although parasite multiplication is evident during acute infection, the intense acute myocarditis of this phase exhibits clear ultrastructural signs of cell-mediated immune damage, inflicted to parasitized and non-parasitized myocardiocytes and to the endothelium of myocardial capillaries (microangiopathy). Inflammation subsides almost completely when immunity decreases parasite load and suppressor factors modulate host reaction, but inflammation does not disappear when the disease enters the indeterminate phase. Inflammation becomes mild and focal and undergoes cyclic changes leading to complete resolution. However, the process is maintained because the disappearance of old focal lesions is balanced by the upsurge of new ones. This equilibrium allows for prolonged host survival in the absence of symptoms or signs of disease. The chronic cardiac form is represented by a delayed-type, cell-mediated diffuse myocarditis, that probably ensues when the suppressive mechanisms, operative during the indeterminate phase, become defaulted. The mechanism responsible for the transition from the indeterminate to the cardiac form, is poorly understood.
Keywords:	Trypanosoma cruzi Immunopathology Myocarditis
DeCS:	Cardiomiopatia Chagásica/imunologia Cardiomiopatia Chagásica/patologia Doença Aguda Animais Doença Crônica Cães Imunidade Celular Microscopia Eletrônica
Issue Date:	1999
Citation:	ANDARDE, Z. A. Immunopathology of Chagas disease. Memórias do Instituto Oswaldo Cruz, v. 94, Suppl 1, p. 71-80, 1999.
ISSN:	0074-0276
Copyright:	open access
Appears in Collections:	BA - IGM - Artigos de Periódicos

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