Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5639
Title: Significance of schistosomal granuloma modulation
Authors: Silva, Luciana Menezes da
Fernandes, André L. M
Barbosa Junior, Aryon de Almeida
Oliveira, Irismar Reis de
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Hepatic Schistosoma mansoni periovular granulomas undergo changes in size, cellular composition and appearance with time. This phenomenon, known as "immunological modulation", has been thought to reflect host immunological status. However, as modulation has not been observed outside the liver, participation of local factors, hitherto little considered, seems crucial. Components of the extracellular matrix of periovular granulomas of the mouse were particularly studied in three different organs (liver, lung and intestine) and during three periods of infection time (acute, intermediate and chronic) by means of histological, biochemical and immunofluorescence techniques, while quantitative data were evaluated by computerized morphometry, in order to investigate participation of local factors in granuloma modulation. Results confirmed modulation as a exclusively hepatic phenomenon, since pulmonary and intestinal granulomas, formed around mature eggs, did not change size and appearance with time. The matricial components which were investigated (Type I, III and IV collagens, fibronectin, laminin, proteoglycans and elastin) were found in all granulomas and in all organs examined. However, their presence was much more prominent in the liver. Elastin was only found in hepatic granulomas of chronic infection. The large amount of extracellular matrix components found in hepatic granulomas was the main change responsible for the morphological aspects of modulation. Therefore, the peculiar environment of the liver ultimately determines the changes identified in schistosomal granuloma as "modulation".
Keywords: Modulation
Granuloma
Shistosomiasis
Extracellular matrix
DeCS: Granuloma/patologia
Enteropatias Parasitárias/patologia
Hepatopatias Parasitárias/patologia
Pneumopatias Parasitárias/patologia
Schistosoma mansoni/imunologia
Esquistossomose mansoni/patologia
Animais
Matriz Extracelular
Feminino
Granuloma/imunologia
Granuloma/parasitologia
Enteropatias Parasitárias/imunologia
Enteropatias Parasitárias/parasitologia
Hepatopatias Parasitárias/imunologia
Hepatopatias Parasitárias/parasitologia
Pneumopatias Parasitárias/imunologia
Masculino
Camundongos
Contagem de Ovos de Parasitas
Esquistossomose mansoni/imunologia
Esquistossomose mansoni/parasitologia
Fatores de Tempo
Issue Date: 2000
Citation: SILVA, L.M. et al. Significance of schistosomal granuloma modulation. Memórias do Instituto Oswaldo Cruz, v. 95, n. 3, p.353-61, may-jun. 2000.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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