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Sustainable Development Goals
03 Saúde e Bem-EstarCollections
- IOC - Artigos de Periódicos [12967]
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COMPARATIVE ANALYSIS OF CIRCULATING LEVELS OF SARS-COV-2 ANTIBODIES AND INFLAMMATORY MEDIATORS IN HEALTHCAREWORKERS AND COVID-19 PATIENTS
COVID-19
Profissionais de saúde
Anticorpos
Citocina
Quimiocinas
Pacientes
Brasil
Author
Affilliation
Abstract
Advances in knowledge of the pathophysiology of COVID-19 have been acquired; however,
the host factors that could explain the mild and severe forms of the disease are not fully understood.
Thus, we proposed to evaluate anti-SARS-CoV-2 antibodies and the inflammatory response of
different groups of individuals, including healthcare workers (HCW), sick and dead COVID-19
patients and also recovered patients to contribute to this knowledge gap. Our objective is to relate
the clinical evolution of these individuals with the level of detection and functionality of specific
antibodies and with the production of inflammatory mediators. As main findings, IgA and IgG
anti-SARS-CoV-2 were detected in asymptomatic HCW. IFN-
and TNF- levels were higher in
symptomatic HCWs than patients with COVID-19 and those who died. Patients who died had
higher levels of IL-6, IL-10, and CCL2/MCP-1. We found an imbalance between antiviral and
pro-inflammatory mediators in the groups, in which IFN-
and TNF- seem to be more associated
with protection and IL-6 and CCL2/MCP-1 with pathology. Our work is pioneering the Brazilian
population and corroborates data from people from other countries.
Keywords in Portuguese
SARS-CoV-2COVID-19
Profissionais de saúde
Anticorpos
Citocina
Quimiocinas
Pacientes
Brasil
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