Author | Roca, Tárcio Peixoto | |
Author | Villar, Livia Melo | |
Author | Lima, Felipe Souza Nogueira | |
Author | Vasconcelos, Mariana Pinheiro Alves | |
Author | Borzacov, Lourdes Maria Pinheiro | |
Author | Silva, Eugênia de Castro e | |
Author | Lago, Bárbara Vieira do | |
Author | Silva, Mayara Torquato Lima da | |
Author | Souza, Luan Felipo Botelho | |
Author | Salcedo, Juan Miguel Villalobos | |
Author | Santos, Alcione de Oliveira dos | |
Author | Vieira, Deusilene Souza | |
Access date | 2023-01-11T17:27:23Z | |
Available date | 2023-01-11T17:27:23Z | |
Document date | 2022 | |
Citation | ROCA, Tárcio Peixoto et al. Article Genomic Variability of Hepatitis B Virus Circulating in BrazilianWestern Amazon. Viruses, v. 14, 2100, p. 1 - 15, Sept. 2022. | en_US |
ISSN | 1999-4915 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/56439 | |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | |
Subject in Portuguese | Mutação | en_US |
Subject in Portuguese | Genótipo | en_US |
Subject in Portuguese | Caracterização clínica | en_US |
Title | Genomic Variability of Hepatitis B Virus Circulating in BrazilianWestern Amazon | en_US |
Type | Article | |
DOI | 10.3390/v14102100 | |
Abstract | The emergence of clinically relevant mutations in the hepatitis B virus (HBV) genome has
been a matter of great debate because of the possibility of escape from the host’s immune system, the
potential to cause more severe progression of liver diseases and the emergence of treatment-resistant
variants. Here we characterized the circulating variants of HBV in Rondônia State, in the north of
Brazil. Serum samples of 62 chronic HBV carriers were subjected to PCR assays and clinical data were
collected. Mutations and genotypes were characterized through direct sequencing. The findings show
the presence of subgenotypes A1 (54.83%, 34/62), D3 (16.13%, 10/62), F2 (16.13%, 10/62), A2 (4.84%,
3/62), D2 (3.23%, 2/62), D1 (1.61%, 1/62), D4 (1.61%, 1/62) and F4 (1.61%, 1/62). Deletions in the
pre-S2 region were found in 13.79% (8/58) of the samples, mutations in the S gene in 59.68% (37/62)
and RT mutations in 48.39% (30/62). We found a variable genotypic distribution in different locations
and important mutations related to immune escape and drug resistance in Western Amazonia, which
contributed to genetic surveillance and provided important information to help control the disease. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz Rondônia. Laboratório de Virologia Molecular. Porto Velho, RO, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz Rondônia. Laboratório de Virologia Molecular. Porto Velho, RO, Brasil. | en_US |
Affilliation | CEPEM/RO. Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brasil. | en_US |
Affilliation | CEPEM/RO. Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brasil. | en_US |
Affilliation | CEPEM/RO. Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Laboratório de Biotecnologia e Bioengenharia Estrutural. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Centro Universitário Aparício Carvalho. Escola de Ciências Biomédicas. Porto Velho, RO, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz Rondônia. Laboratório de Virologia Molecular. Porto Velho, RO, Brasil / CEPEM/RO. Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brasil. | en_US |
Affilliation | Centro Universitário Aparício Carvalho. Escola de Ciências Biomédicas. Porto Velho, RO, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz Rondônia. Laboratório de Virologia Molecular. Porto Velho, RO, Brasil / CEPEM/RO. Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brasil / Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brasil. | en_US |
Subject | Mutation | en_US |
Subject | Genotype | en_US |
Subject | Clinical characterization | en_US |