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GENOMIC VARIABILITY OF HEPATITIS B VIRUS CIRCULATING IN BRAZILIANWESTERN AMAZON
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Abstract
The emergence of clinically relevant mutations in the hepatitis B virus (HBV) genome has
been a matter of great debate because of the possibility of escape from the host’s immune system, the
potential to cause more severe progression of liver diseases and the emergence of treatment-resistant
variants. Here we characterized the circulating variants of HBV in Rondônia State, in the north of
Brazil. Serum samples of 62 chronic HBV carriers were subjected to PCR assays and clinical data were
collected. Mutations and genotypes were characterized through direct sequencing. The findings show
the presence of subgenotypes A1 (54.83%, 34/62), D3 (16.13%, 10/62), F2 (16.13%, 10/62), A2 (4.84%,
3/62), D2 (3.23%, 2/62), D1 (1.61%, 1/62), D4 (1.61%, 1/62) and F4 (1.61%, 1/62). Deletions in the
pre-S2 region were found in 13.79% (8/58) of the samples, mutations in the S gene in 59.68% (37/62)
and RT mutations in 48.39% (30/62). We found a variable genotypic distribution in different locations
and important mutations related to immune escape and drug resistance in Western Amazonia, which
contributed to genetic surveillance and provided important information to help control the disease.
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