Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5647
Title: Clonally related penicillin-nonsusceptible Streptococcus pneumoniae serotype 14 from cases of meningitis in Salvador, Brazil.
Authors: Ko, Albert Icksang
Reis, Joice Neves
Coppola, Steven J
Gouveia, Edilane Lins
Cordeiro, Soraia Machado
Lôbo, Tatiana Silva
Pinheiro, Ricardo M
Salgado, Kátia M
Dourado, Cibele M. Ribeiro
Tavares Neto, José
Rocha, Heonir
Reis, Mitermayer Galvão dos
Johnson Junior, Warren D
Riley, Lee Woodland
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Cornell University Medical College. Division of International Medicine and Infectious Diseases. New York, New York
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Secretaria de Saúde do Estado da Bahia. Hospital Couto Maia. Salvador, Bahia, Brasil
Secretaria de Saúde do Estado da Bahia. Hospital Couto Maia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Cornell University Medical College. Division of International Medicine and Infectious Diseases. New York, New York
University of California at Berkeley. Division of Public Health Biology and Epidemiology. Berkeley, CA, United States of America
Abstract: Active hospital-based surveillance in the city of Salvador, Brazil, from December 1995 through October 1998, identified 221 patients with confirmed pneumococcal meningitis. Of these 221 patients, 29 (13%) had isolates with intermediate-level resistance to penicillin. Infection with these penicillin-nonsusceptible isolates was significantly associated with age of <2 years (P<.0019), previous antibiotic use (P<.0006), and coresistance to trimethoprim-sulfamethoxazole (P<.0000). Serotype 14 was the most prevalent serotype (55.2%) of penicillin-nonsusceptible isolates. Strain typing by repetitive element BOX polymerase chain reaction (PCR) analysis showed that penicillin-nonsusceptible serotype 14 isolates had closely related BOX PCR patterns, whereas penicillin-susceptible serotype 14 isolates each had distinct, unrelated patterns. Penicillin-nonsusceptible serotype 14 isolates from Salvador and other Brazilian cities had similar BOX PCR patterns. These observations indicate that in Brazil a large proportion of cases of penicillin-nonsusceptible pneumococcal meningitis appear to be caused by a closely related group of serotype 14 strains that may have disseminated to widely separate geographic areas.
DeCS: Meningite Pneumocócica/epidemiologia
Meningite Pneumocócica/microbiologia
Resistência às Penicilinas
Streptococcus pneumoniae/classificação
Streptococcus pneumoniae/efeitos de drogas
Adolescente
Adulto
Antibacterianos/farmacologia
Brasil/epidemiologia
Criança
Pré-Escolar
Humanos
Lactente
Recém-Nascido
Testes de Sensibilidade Microbiana
Reação em Cadeia da Polimerase/métodos
Vigilância da População
Fatores de Risco
Sorotipagem
Streptococcus pneumoniae/genética
Streptococcus pneumoniae/isolamento & purificação
Issue Date: 2000
Citation: KO, A.I. et al. Clonally related penicillin-nonsusceptible Streptococcus pneumoniae serotype 14 from cases of meningitis in Salvador, Brazil. Clinical Infectious of Diseases, v. 30, n. 1, p. 78-86, jan. 2000.
ISSN: 1058-4838
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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