Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5664
Title: Histopathologic features associated with susceptibility and resistance of Biomphalaria snails to infection with Schistosoma mansoni
Authors: Borges, Claudia Maria da Cunha
Souza, Cecília Pereira de
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Resistance and susceptibility of Biomphalaria snails to Schistosoma mansoni sporocysts occur in different degrees. Histopathology reflects these differences. In a state of tolerance numerous sporocysts in different stages of differentiation are seen in the absence of host tissue reaction. However extensive diffuse and focal proliferation of amebocytes with sequestration and destruction of many parasitic structures appear in resistant snails. Some snails are totally resistant and when exposed to infecting miracidia may never eliminate cercarie. Sequential histopathological examination has revealed that in such cases the infected miracidia are destroyed a few minutes to 24 hr after penetration in the snail. However, B. glabrata that were exposed to S. mansoni miracidia and three months later failed to shed cercariae, exhibited focal and diffuse proliferation of amebocytes in many organs in the absence of pasitic structures. These lesions were similar to those observed in resistant snails that were still eliminating a few cercariae, with the difference that no recognizable sporocystic structures or remnants were present. Histological investigation carried out in similarly resistant B. tenagophila and B. straminea presented essentially normal histologic structures. Only occasionally a few focal proliferative (granulomatous) amebocytic reactions were seen in ovotestis and in the tubular portion of the kidney. Probably, there are two types of reactions to miracidium presented by totally resistant snails: one would implicate the immediate destruction of the miracidium leaving no traces in the tissues; the other involving late reactions that seem to completely destroy invading sporocysts and leave histological changes.
Keywords: Snails
Schistosoma mansoni -
Susceptibility
Resistance
Histopathology
DeCS: Biomphalaria/parasitologia
Schistosoma mansoni/patogenicidade
Animais
Biomphalaria/fisiologia
Interações Hospedeiro-Parasita/fisiologia
Issue Date: 1998
Citation: BORGES, C.M.; de SOUZA, C.P.; ANDRADE, Z.A. Histopathologic features associated with susceptibility and resistance of Biomphalaria snails to infection with Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, v. 93, Suppl 1, p. 117-21, 1998.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos
BA - IGM - Artigos de Periódicos

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