| Author | Toledo, Sílvia Letícia de Oliveira | |
| Author | Ladeira, Valéria Sutana | |
| Author | Nogueira, Leilismara Sousa | |
| Author | Ferreira, Letícia Gonçalves Resende | |
| Author | Oliveira, Marina Mendes | |
| Author | Renó, Cristiane de Oliveira | |
| Author | Santos, Hérica Lima Dos | |
| Author | Reis, Jordana Grazziela Alves Coelho dos | |
| Author | Azevedo, Ana Carolina Campi | |
| Author | Carvalho, Andréa Teixeira de | |
| Author | Martins Filho, Olindo Assis | |
| Author | Rios, Danyelle Romana Alves | |
| Author | Pinheiro, Melina Barros | |
| Access date | 2023-01-26T18:48:13Z | |
| Available date | 2023-01-26T18:48:13Z | |
| Document date | 2022 | |
| Citation | TOLEDO, Sílvia Letícia de Oliveira et al. Plasma immune mediators as laboratorial biomarkers for Sickle Cell Disease patients according to the hydroxyurea therapy and disease severity. Blood Cells, Molecules, and Diseases, v. 98, p. 102703, 2023. Doi: 10.1016/j.bcmd.2022.102703 | en_US |
| ISSN | 1079-9796 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56642 | |
| Language | eng | en_US |
| Publisher | Academic Press | en_US |
| Rights | restricted access | |
| Title | Plasma immune mediators as laboratorial biomarkers for Sickle Cell Disease patients according to the hydroxyurea therapy and disease severity | en_US |
| Type | Article | |
| Abstract | In the present work, the impact of Sickle Cell Disease (SCD) degrees of severity, as well hydroxyurea treatment on the systemic immunological signatures of patients was evaluated. Based on a high-throughput chemokine, cytokine and growth factor multiplex analysis, it was possible to obtain the systemic immunological profile of patients with SCD (n = 40), treated or not with hydroxyurea, as compared to healthy controls (n = 40). Overall, SCD patients with severe disease displayed increased levels of almost all biomarkers analyzed. Our data demonstrated that CXCL8, CCL3 and CXCL10 were pointed out as universal biomarkers of SCD. The results also indicated that HU-untreated patients with indication of HU-therapy display a more prominent increase on plasma immune mediators in a similar way as those with severe SCD disease. Together, these findings provided a comprehensive landscape of evidence that may have implications for further therapeutic strategies and SCD clinical management. | en_US |
| Affilliation | Universidade Federal de São João del-Rei. Divinópolis, MG, Brazil. | en_US |
| Affilliation | Fundação Centro de Hematologia e Hemoterapia do Estado de Minas Gerais. Hemonúcleo Regional de Divinópolis. Divinópolis, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Alfenas. Departamento de Análises Clínica e Toxicológicas. Alfenas, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de São João del-Rei. Divinópolis, MG, Brazil. | en_US |
| Affilliation | Fundação Centro de Hematologia e Hemoterapia do Estado de Minas Gerais. Hemonúcleo Regional de Divinópolis. Divinópolis, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de São João del-Rei. Divinópolis, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de São João del-Rei. Divinópolis, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de São João del-Rei. Divinópolis, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de São João del-Rei. Divinópolis, MG, Brazil. | en_US |
| Subject | Biomarkers | en_US |
| Subject | Cytokine | en_US |
| Subject | Hydroxyurea | en_US |
| Subject | Inflammation | en_US |
| Subject | Sickle Cell Disease | en_US |
| Embargo date | 2099-12-31 | |
