Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5674
Title: Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi.
Authors: Andrade, Sonia Gumes
Carneiro Filho, Aydano
Souza, André J. Maia de
Lima, Elianita Suzart de
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Latent Trypanosoma cruzi infection may be reactivated in immunosuppressed individuals, with unusual clinical patterns, such as meningoencephalitis, pseudo neoplastic lesions in the central nervous system, and myocarditis with numerous parasites in the heart muscle. To investigate this problem 68 Swiss mice chronically infected with different strains of T. cruzi were treated with different combinations of immunosuppressive drugs (azathioprine, cyclosporine and betamethasone), in such a way as to imitate the situation during post transplantation treatment. Mortality varied from 6 to 25% in treated mice. There were no deaths in untreated controls. Normal mice have been submitted to the same schedules of immunosuppression as controls of treatment and no deaths were registered during treatment. Chronically infected mice showed significant elevation of total number of leukocytes and lymphocytes in comparison with intact controls; a significant decrease in blood leukocytes and lymphocytes occurred post-treatment in two of the treated experimental groups. Exacerbation of myocarditis and myositis and a high incidence of brain lesions, with focal necrosis, granulomatous lesions and glial proliferation even in the absence of parasites were present in immunosuppressed mice but not in infected controls. Although differing in some aspects from Chagas' disease in immunosuppressed humans, the murine model did show some features that resembled it, especially the peculiar pattern of central nervous system involvement.
Keywords: Trypanosoma cruzi
Immunosuppression
Azathioprine
Cyclosporine
Betamethasone
DeCS: Doença de Chagas/imunologia
Modelos Animais de Doenças
Imunossupressores/efeitos adversos
Animais
Anticorpos Anti-Helmínticos/sangue
Azatioprina/efeitos adversos
Betametasona/efeitos adversos
Encéfalo/parasitologia
Doença Crônica
Ciclosporina/efeitos adversos
Contagem de Leucócitos
Contagem de Linfócitos
Camundongos
Camundongos Endogâmicos
Recidiva
Transplante
Issue Date: 1997
Citation: ANDRADE, S. G. et al. Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi. International Journal of Experiemental Pathology, v. 78, n. 6, p. 391-9, dec. 1997.
ISSN: 0959-9673
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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