Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/56849

Type
Article
Copyright
Open access
Sustainable Development Goals
05 Igualdade de gênero
Collections
Share

Statistics
Metadata
Show full item record

THE GENOMIC IMPACT OF EUROPEAN COLONIZATION OF THE AMERICAS
Ongaro, Linda et al. | Date Issued: 2019
Author
Ongaro, Linda
Scliar, Marilia O.
Flores, Rodrigo
Raveane, Alessandro
Marnetto, Davide
Sarno, Stefania
Gnecchi-Ruscone, Guido A.
Alarcón-Riquelme, Marta E.
Patin, Etienne
Wangkumhang, Pongsakorn
Hellenthal, Garrett
Santos, Miguel Gonzalez
King, Roy J.
Kouvatsi, Anastasia
Balanovsky, Oleg
Balanovska, Elena
Atramentova, Lubov
Turdikulova, Shahlo
Mastana, Sarabjit
Marjanovic, Damir
Mulahasanovic, Lejla
Leskovac, Andreja
Costa, Maria F. Lima
Pereira, Alexandre C.
Barreto, Mauricio L.
Horta, Bernardo L.
Mabunda, Nedio
May, Celia A.
Moreno-Estrada, Andres
Achilli, Alessandro
Olivieri, Anna
Semino, Ornella
Tambets, Kristiina
Kivisild, Toomas
Luiselli, Donata
Torroni, Antonio
Capelli, Cristian
Santos, Eduardo Tarazona
Metspalu, Mait
Pagani, Luca
Montinaro, Francesco
Affilliation
Estonian Biocentre. Institute of Genomics. Riia, Tartu, Estonia / Department of Evolutionary Biology. Institute of Molecular and Cell Biology. Riia, Tartu, Estonia.
Universidade de São Paulo. Instituto de Biociências. Centro de Pesquisas do Genoma Humano e Células Tronco. São Paulo, SP, Brasil / Universidade Federal de Minas Gerais. Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil.
Estonian Biocentre. Institute of Genomics. Riia, Tartu, Estonia.
Department of Biology and Biotechnology ‘‘L. Spallanzani’’. University of Pavia. Pavia, Italy.
Estonian Biocentre. Institute of Genomics. Riia, Tartu, Estonia.
Department of Biological. Geological and Environmental Sciences. University of Bologna. Bologna, Italy.
Department of Biological. Geological and Environmental Sciences. University of Bologna. Bologna, Italy / Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena 07745, Germany.
GENYO. Centre for Genomics and Oncological Research. Pfizer/University of Granada/Andalusian Regional Government. Granada, Spain.
Human Evolutionary Genetics Unit. Pasteur Institute. Paris, France.
Department of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London WC1E 6BT, UK.
Department of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London WC1E 6BT, UK.
Department of Zoology. University of Oxford. Oxford, UK.
Department of Psychiatry and Behavioral Sciences. Stanford University School of Medicine. Stanford, USA.
Department of Genetics. Development and Molecular Biology. School of Biology. Aristotle University of Thessaloniki. Thessaloniki, Greece.
Vavilov Institute of General Genetics. Ulitsa Gubkina, Moscow, Russia / Research Centre for Medical Genetics. Moskvorech’ye Ulitsa, Moscow, Russia / Biobank of North Eurasia. Kotlyakovskaya Ulitsa, strpfojf, Moscow, Russia.
Vavilov Institute of General Genetics. Ulitsa Gubkina, Moscow, Russia / Research Centre for Medical Genetics. Moskvorech’ye Ulitsa, Moscow, Russia / Biobank of North Eurasia. Kotlyakovskaya Ulitsa, strpfojf, Moscow, Russia.
Department of Genetics and Cytolog. V.N. Karazin Kharkiv National University. Kharkiv, Ukraine.
Laboratory of Genomics. Institute of Bioorganic Chemistry. Academy of Sciences Republic of Uzbekistan. Tashkent, Uzbekistan.
School of Sport. Exercise and Health Sciences. Loughborough University. Loughborough, UK.
Department of Genetics and Bioengineering. Faculty of Engineering and Information Technologies. International Burch University. Sarajevo, Bosnia, and Herzegovina / Institute for Anthropological Research. Zagreb, Croatia.
CeGaT GmbH. Tübingen. Praxis für Humangenetik, Tübingen, Germany.
Vinca Institute of Nuclear Sciences. University of Belgrade. M. Petrovica Alasa, Belgrade, Serbia.
Fundação Oswaldo Cruz. Instituto de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil.
Universidade de São Paulo. Instituto do Coração. São Paulo, SP, Brasil.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.
Universidade Federal de Pelotas. Programa de Pós-graduação em Epidemiologia. Pelotas, RS, Brasil.
Instituto Nacional de Saúde. Distrito de Marracuene. Provıncia de Maputo, Mozambique.
Department of Genetics & Genome Biology. University of Leicester. Leicester, UK.
National Laboratory of Genomics for Biodiversity (LANGEBIO). CINVESTAV. Irapuato, Guanajuato, Mexico.
Department of Biology and Biotechnology ‘‘L. Spallanzani’’. University of Pavia. Pavia, Italy.
Department of Biology and Biotechnology ‘‘L. Spallanzani’’. University of Pavia. Pavia, Italy.
Department of Biology and Biotechnology ‘‘L. Spallanzani’’. University of Pavia. Pavia, Italy.
Estonian Biocentre. Institute of Genomics. Riia, Tartu, Estonia.
Department of Human Genetics. KU Leuven. Herestraat, Leuven, Belgium.
Department of Cultural Heritage. University of Bologna. Ravenna Campus, Ravenna, Italy.
Department of Biology and Biotechnology ‘‘L. Spallanzani’’. University of Pavia. Pavia, Italy.
Department of Zoology. University of Oxford. Oxford, UK.
Universidade Federal de Minas Gerais. Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil.
Estonian Biocentre. Institute of Genomics. Riia, Tartu, Estonia.
Estonian Biocentre. Institute of Genomics. Riia, Tartu, Estonia / Department of Biology. University of Padua. Via Ugo Bassi, Padua, Italy.
Estonian Biocentre. Institute of Genomics. Riia, Tartu, Estonia / Department of Zoology. University of Oxford. Oxford, UK.
Abstract
The human genetic diversity of the Americas has been affected by several events of gene flow that have continued since the colonial era and the Atlantic slave trade. Moreover, multiple waves of migration followed by local admixture occurred in the last two centuries, the impact of which has been largely unexplored. Here, we compiled a genome-wide dataset of ∼12,000 individuals from twelve American countries and ∼6,000 individuals from worldwide populations and applied haplotype-based methods to investigate how historical movements from outside the New World affected (1) the genetic structure, (2) the admixture profile, (3) the demographic history, and (4) sex-biased gene-flow dynamics of the Americas. We revealed a high degree of complexity underlying the genetic contribution of European and African populations in North and South America, from both geographic and temporal perspectives, identifying previously unreported sources related to Italy, the Middle East, and to specific regions of Africa.
Keywords in Portuguese
Comércio de escravos no atlântico
Colonização europeia
História da mistura das Américas
Mistura tendenciosa do sexo.
 
Keywords
Atlantic slave trade
European colonization
Admixture history of the Americas
Sex-biased admixture
 
Publisher
Cell Press
Citation
ONGARO, Linda et al. The genomic impact of european colonization of the americas. Current Biology, v. 29, p. 1-18, 2019.
DOI
10.1016/j.cub.2019.09.076
ISSN
1879-0445