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A NEW WHO BOTTLE BIOASSAY METHOD TO ASSESS THE SUSCEPTIBILITY OF MOSQUITO VECTORS TO PUBLIC HEALTH INSECTICIDES: RESULTS FROM A WHO-COORDINATED MULTI-CENTRE STUDY
Corbel, Vincent et al. | Date Issued: 2023
Author
Corbel, Vincent
Kont, Mara D.
Ahumada, Martha Liliana
Andréo, Laura
Bayili, Bazoma
Bayili, Koama
Broke, Basil
Caballero, Jesús A. Pinto
Lambert, Ben
Churcher, Thomas S.
Duchon, Stephane
Etang, Josiane
Flores, Adriana E.
Gunasekaran, Kasinathan
Juntarajumnong, Waraporn
Kirby, Matt
Davies, Rachel
Lees, Rosemary Susan
Lenhart, Audrey
LIma, José Bento Pereira
Martins, Ademir J.
Müller, Pie
N’Guessan, Raphael
Ngufor, Corine
Praulins, Giorgio
Quinones, Martha
Raghavendra, Kamaraju
Verma, Vaishali
Rus, Adanan Che
Sin Ying, Koou
Sungvornyothin, Sungsit
Uragayala, Sreehari
Velayudhan, Raman
Yadav, Rajpal S.
Affilliation
Institut de Recherche pour le Développement (IRD), MIVEGEC, CNRS, IRD, Université de Montpellier, Montpellier, France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil.
MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London. Norfolk Place, London, UK.
Instituto Nacional de Salud. Grupo de Entomología. Bogotá, Colombia.
Institut de Recherche pour le Développement. Université de Montpellier. Montpellier, France.
Institut de Recherche en Sciences de la Santé. Bobo-Dioulasso, Burkina Faso.
Institut de Recherche en Sciences de la Santé. Bobo-Dioulasso, Burkina Faso.
Centre for Emerging Zoonotic and Parasitic Diseases. National Institute for Communicable Diseases. Wits Research Institute for Malaria. Faculty of Health Sciences. University of the Witwatersrand. Johannesburg, South Africa.
Instituto Nacional de Salud. Laboratorio de Referencia Nacional de Entomología (LRNE), Centro Nacional de Salud Pública. Lima, Peru.
Department of Mathematics. University of Exeter. North Park Rd, UK.
MRC Centre for Global Infectious Disease Analysis. Department of Infectious Disease Epidemiology. Imperial College London. London, UK.
Institut de Recherche pour le Développement. Université de Montpellier. Montpellier, France.
Laboratoire de Recherche sur le Paludisme. Institut de Recherche de Yaoundé. Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale. Yaoundé, Cameroun / Department of Biological Sciences. Faculty of Medicine and Pharmaceutical Sciences. University of Douala. Douala, Cameroon.
Facultad de Ciencias Biologicas. Laboratorio de Entomologia Medica. Universidad Autónoma de Nuevo León. San Nicolas de los Garza, NL, Mexico.
Indian Council of Medical Research. Vector Control Research Centre. Indira Nagar, India.
Department of Entomology. Faculty of Agriculture. Kasetsart University. Bangkok, Thailand.
Kilimanjaro Christian Medical Centre. Kilimanjaro Christian Medical University College. he Pan African Malaria Vector Research Consortium. Kilimanjaro, Tanzania / London School of Hygiene and Tropical Medicine. London, UK.
Vector Biology Department. Liverpool School of Tropical Medicine. Liverpool, UK.
Vector Biology Department. Liverpool School of Tropical Medicine. Liverpool, UK.
Entomology Branch. Centers for Disease Control and Prevention. Atlanta, GA, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil.
Swiss Tropical and Public Health Institute. Allschwil, Switzerland / University of Basel. Basel, Switzerland.
London School of Hygiene and Tropical Medicine. London, UK / Face Ecole des Infrmiers. Institut Pierre Richet. Institut National de Santé Publique. Bouaké, Côte d’Ivoire.
London School of Hygiene and Tropical Medicine. London, UK / Centres de Recherches Entomologiques de Cotonou. Ministère de la santé du Bénin. Cotonou, Benin.
Vector Biology Department. Liverpool School of Tropical Medicine. Liverpool, UK.
Public Health Department. Faculty of Medicine, Universidad Nacional de Colombia. Bogota, Colombia.
Indian Council of Medical Research. National Institute of Malaria Research. New Delhi, India.
Indian Council of Medical Research. National Institute of Malaria Research. New Delhi, India.
Vector Control Research Unit. School of Biological Sciences. Universiti Sains Malaysia. Penang, Malaysia.
Centre for Emerging Zoonotic and Parasitic Diseases. National Institute for Communicable Diseases. NHLS and Wits Research Institute for Malaria. Faculty of Health Sciences. University of the Witwatersrand. Johannesburg, South Africa.
Environmental Health Institute. National Environmental Agency. Singapore.
Department of Medical Entomology. Faculty of Tropical Medicine. Mahidol University. Bangkok, Thailand.
Field Unit. Indian Council of Medical Research. National Institute of Malaria Research. Poojanahalli, Kannamangla Post. Bengaluru, India.
Vector Control. Veterinary Public Health and Environment Unit. Department of Control of Neglected Tropical Diseases. World Health Organization. Geneva, Switzerland.
Vector Control. Veterinary Public Health and Environment Unit. Department of Control of Neglected Tropical Diseases. World Health Organization. Geneva, Switzerland.
Abstract
Abstract Background The continued spread of insecticide resistance in mosquito vectors of malaria and arboviral diseases may lead to operational failure of insecticide-based interventions if resistance is not monitored and managed efciently. This study aimed to develop and validate a new WHO glass bottle bioassay method as an alternative to the WHO standard insecticide tube test to monitor mosquito susceptibility to new public health insecticides with particular modes of action, physical properties or both. Methods A multi-centre study involving 21 laboratories worldwide generated data on the susceptibility of seven mosquito species (Aedes aegypti, Aedes albopictus, Anopheles gambiae sensu stricto [An. gambiae s.s.], Anopheles funestus, Anopheles stephensi, Anopheles minimus and Anopheles albimanus) to seven public health insecticides in fve classes, including pyrethroids (metofuthrin, prallethrin and transfuthrin), neonicotinoids (clothianidin), pyrroles (chlorfenapyr), juvenile hormone mimics (pyriproxyfen) and butenolides (fupyradifurone), in glass bottle assays. The data were analysed using a Bayesian binomial model to determine the concentration–response curves for each insecticide–species combination and to assess the within-bioassay variability in the susceptibility endpoints, namely the concentration that kills 50% and 99% of the test population (LC50 and LC99, respectively) and the concentration that inhibits oviposition of the test population by 50% and 99% (OI50 and OI99), to measure mortality and the sterilizing efect, respectively.
Keywords in Portuguese
Aedes
Anopheles
Resistência a inseticidas
Inseticidas de saúde pública
Teste de suscetibilidade
Controle de vetores
Bioensaio de garrafa da OMS
Concentrações discriminantes
 
Keywords
Aedes
Anopheles
Insecticide resistance
Public health insecticides
Susceptibility test
Vector control
WHO bottle bioassay
Discriminating concentrations
 
Publisher
BMC
Citation
CORBEL, Vincent et al. A new WHO bottle bioassay method to assess the susceptibility of mosquito vectors to public health insecticides: results from a WHO-coordinated multi-centre study. Parasites & Vectors, v. 16, n. 21, p. 1-17, 2023.
DOI
10.1186/s13071-022-05554-7
ISSN
1756-3305