Author | Souza, Márcia Maria de | |
Author | Andrade, Sonia Gumes | |
Author | Barbosa Junior, Aryon de Almeida | |
Author | Santos, Raimunda Telma Macedo | |
Author | Alves, Venâncio Avancini Ferreira | |
Author | Andrade, Zilton de Araújo | |
Access date | 2012-10-19T19:46:33Z | |
Available date | 2012-10-19T19:46:33Z | |
Document date | 1996 | |
Citation | de SOUZA, M.M. et al. Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, v. 91, n. 2, p. 217-24, mar.-apr. 1996. | pt_BR |
ISSN | 0074-0276 | |
URI | https://www.arca.fiocruz.br/handle/icict/5695 | |
Language | eng | pt_BR |
Rights | open access | |
Title | Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. | pt_BR |
Type | Article | pt_BR |
Abstract | Lesions involving the sympathetic (para-vertebral ganglia) and para-sympathetic ganglia of intestines
(Auerbach plexus) and heart (right atrial ganglia) were comparatively analyzed in mice infected
with either of three different strain types of Trypanosoma cruzi, during acute and chronic infection, in
an attempt to understand the influence of parasite strain in causing autonomic nervous system pathology.
Ganglionar involvement with neuronal destruction appeared related to inflammation, which most
of the times extended from neighboring adipose and cardiac, smooth and striated muscular tissues.
Intraganglionic parasitism was exceptional. Inflammation involving peripheral nervous tissue exhibited
a focal character and its variability in the several groups examined appeared unpredictable. Although
lesions were generally more severe with the Y strain, comparative qualitative study did not allow
the conclusion, under the present experimental conditions, that one strain was more pathogenic to the
autonomic nervous system than others. No special tropism of the parasites from any strain toward autonomic
ganglia was disclosed. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Instituto Adolfo Lutz. São Paulo, SP, Brasil | pt_BR |
Affilliation | Instituto Adolfo Lutz. São Paulo, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Strain-types | pt_BR |
Subject | Autonomic nervous system | pt_BR |
DeCS | Sistema Nervoso Autônomo/patologia | pt_BR |
DeCS | Doença de Chagas/patologia | pt_BR |
DeCS | Trypanosoma cruzi/classificação | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Sistema Nervoso Autônomo/parasitologia | pt_BR |
DeCS | Cardiomiopatia Chagásica/parasitologia | pt_BR |
DeCS | Cardiomiopatia Chagásica/patologia | pt_BR |
DeCS | Doença de Chagas/parasitologia | pt_BR |
DeCS | Modelos Animais de Doenças | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Camundongos | pt_BR |