Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5695
Title: Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease.
Authors: Souza, Márcia Maria de
Andrade, Sonia Gumes
Barbosa Junior, Aryon de Almeida
Santos, Raimunda Telma Macedo
Alves, Venâncio Avancini Ferreira
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Instituto Adolfo Lutz. São Paulo, SP, Brasil
Instituto Adolfo Lutz. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Lesions involving the sympathetic (para-vertebral ganglia) and para-sympathetic ganglia of intestines (Auerbach plexus) and heart (right atrial ganglia) were comparatively analyzed in mice infected with either of three different strain types of Trypanosoma cruzi, during acute and chronic infection, in an attempt to understand the influence of parasite strain in causing autonomic nervous system pathology. Ganglionar involvement with neuronal destruction appeared related to inflammation, which most of the times extended from neighboring adipose and cardiac, smooth and striated muscular tissues. Intraganglionic parasitism was exceptional. Inflammation involving peripheral nervous tissue exhibited a focal character and its variability in the several groups examined appeared unpredictable. Although lesions were generally more severe with the Y strain, comparative qualitative study did not allow the conclusion, under the present experimental conditions, that one strain was more pathogenic to the autonomic nervous system than others. No special tropism of the parasites from any strain toward autonomic ganglia was disclosed.
Keywords: Trypanosoma cruzi
Strain-types
Autonomic nervous system
DeCS: Sistema Nervoso Autônomo/patologia
Doença de Chagas/patologia
Trypanosoma cruzi/classificação
Animais
Sistema Nervoso Autônomo/parasitologia
Cardiomiopatia Chagásica/parasitologia
Cardiomiopatia Chagásica/patologia
Doença de Chagas/parasitologia
Modelos Animais de Doenças
Feminino
Masculino
Camundongos
Issue Date: 1996
Citation: de SOUZA, M.M. et al. Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, v. 91, n. 2, p. 217-24, mar.-apr. 1996.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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