Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5699
Title: Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi.
Authors: Magalhães, Juracy Barbosa
Andrade, Sonia Gumes
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Seventy Swiss mice chronically infected with different strains of Trypanosoma cruzi, with persistently negative parasitemia on routine blood examination were parasitologically investigated to find out whether spontaneous cure occurred. Duration of infection varied from 90 to 250 days in the initial phase of this investigation. Parasitological tests consisted of daily direct blood examination performed during at least 25 days, followed by xenodiagnosis and subinoculation of blood into newborn mice. Mice that persisted negative were treated with Cyclophosphamide with one dose of 250 mg/kg of body weight and then investigated by direct blood examination, xenodiagnosis and subinoculation. A second dose of 250 mg/kg b. w. was given to the persistently negative mice. With one single exception, all mice showed positive parasitological tests in the different stages of the present investigation and we conclude that spontaneous cure did not occur in this group, which is representative of the chronic infection with different strains of T. cruzi.
Keywords: Trypanosoma cruzi
Spontaneous cure
Chronic infection
Murine model
Cyclophosphamide
DeCS: Doença de Chagas/parasitologia
Animais
Doença de Chagas /diagnóstico
Doença de Chagas /quimioterapia
Doença Crônica
Ciclofosfamida/administração & dosagem
Ciclofosfamida/uso terapêutico
Camundongos
Remissão Espontânea
Fatores de Tempo
Trypanosoma cruzi/efeitos de drogas
Trypanosoma cruzi/isolamento & purificação
Issue Date: 1994
Citation: MAGALHÃES, J.B.; ANDRADE, S.G. Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi. Revista do Instituto de Medicina Tropical de São Paulo, v. 36, p. 6, p. 481-4, nov.-dec. 1994.
ISSN: 0036-4665
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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