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2090-12-31
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PEPTIDE MICROARRAYS FOR FLAVIVIRUS DIAGNOSIS
Author
Affilliation
National Research Council of Italy. Istituto di Scienze e Tecnologie Chimiche. Rome, Italy / Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil / Prefeitura de Belo Horizonte. Secretaria Municipal de Saúde de Belo Horizonte. Gerência da Rede Ambulatorial Especializada. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.
Vaccine Research and Development Center. Department of Physiology. University of California. Irvine, CA, USA.
Vaccine Research and Development Center. Department of Physiology. University of California. Irvine, CA, USA.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil / Vaccine Research and Development Center. Department of Physiology. University of California. Irvine, CA, USA.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil / Prefeitura de Belo Horizonte. Secretaria Municipal de Saúde de Belo Horizonte. Gerência da Rede Ambulatorial Especializada. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.
Vaccine Research and Development Center. Department of Physiology. University of California. Irvine, CA, USA.
Vaccine Research and Development Center. Department of Physiology. University of California. Irvine, CA, USA.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil / Vaccine Research and Development Center. Department of Physiology. University of California. Irvine, CA, USA.
Abstract
Flavivirus are the most alarming prevalent viruses worldwide due to its vast impact on public health. Most early symptoms of diseases caused by Flavivirus are similar among each other and to other febrile illnesses making the clinical differential diagnosis challenging. In addition, due to cross-reactivity and a relatively limited persistence of viral RNA in infected individuals, the current available diagnosis strategies fail to efficiently provide a differential viral identification. In this context, virus-specific tests are essential to improve patient care, as well as to facilitate disease surveillance and the effective control of transmission. Here, we describe the use of protein microarrays as an effective tool for screening peptides differentially recognized by anti-Yellow Fever virus antibodies induced by vaccination or by natural viral infection.
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