Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5707
Title: Pathology of periportal fibrosis involution in human schistosomiasis.
Authors: Andrade, Zilton de Araújo
Peixoto, Ediriomar
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital Central Roberto Santos. Salvador, BA, Brasil
Abstract: Optical and electron microscopical evidences of focal matrix degradation were frequently seen in liver sections of periportal fibrosis caused by schistosomiasis mansoni in man. The material came from 14 wedge hepatic biopsies taken from patients with chronic advanced hepatosplenic disease and undergoing operations for the relief of portal hypertension. Besides the presence of focal areas of rarefaction, fragmentation and dispersion of collagen fibers, the enlarged portal spaces also showed hyperplasia of elastic tissue and disarray of smooth muscle fibers following destruction of portal vein branches. Eggs were scanty in the tissue sections, and matrix degradation probably represented involuting changes related to the progressive diminution of parasite-related aggression, which occurs spontaneously with age or after cure by chemotherapy. The changes indicative of matrix degradation now described are probably the basic morphological counterpart of periportal fibrosis involution currently being documented by ultrasonography in hepatosplenic patients submitted to curative chemotherapy.
Keywords: Matrix degradation
Fibrosis
Schistosomiasis
Collagen
Chemotherapy
DeCS: Fígado/patologia
Esquistossomose mansoni/patologia
Adolescente
Adulto
Biópsia
Colágeno/metabolismo
Feminino
Fibrose
Hepatomegalia/etiologia
Hepatomegalia/metabolismo
Hepatomegalia/patologia
Humanos
Imunoistoquímica
Fígado/metabolismo
Masculino
Microscopia Eletrônica
Meia-Idade
Esquistossomose mansoni/complicações
Esquistossomose mansoni/metabolismo
Esplenomegalia/etiologia
Esplenomegalia/metabolismo
Esplenomegalia/patologia
Issue Date: 1992
Citation: ANDRADE, Z.A.; PEIXOTO, E. Pathology of periportal fibrosis involution in human schistosomiasis. Revista do Instituto de Medicina Tropical de São Paulo, v. 34, n. 4, p. 263-72, jul.-aug. 1992.
ISSN: 0036-4665
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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