| Author | Fernandez, José Carlos Couto | |
| Author | Morgado, Mariza Gonçalves | |
| Author | Santos, Jairo Ivo dos | |
| Author | Castro Filho, Bernardo Galvão | |
| Access date | 2012-10-22T19:08:59Z | |
| Available date | 2012-10-22T19:08:59Z | |
| Document date | 1992 | |
| Citation | COUTO-FERNANDEZ, J.C. et al. Molecular and biological diversity of HIV-1 in Brazil. Memórias do Instituto Oswaldo Cruz, v. 87, n. 2, p. 249-55, apr.-jun. 1992. | pt_BR |
| ISSN | 0074-0276 | |
| URI | https://www.arca.fiocruz.br/handle/icict/5708 | |
| Language | eng | pt_BR |
| Rights | open access | |
| Title | Molecular and biological diversity of HIV-1 in Brazil. | pt_BR |
| Type | Article | pt_BR |
| Abstract | To determine the genomic polymorphism and biological properties present in HIV-1 Brazilian isolates, we analyzed five viral isolates obtained from patients residing in Rio de Janeiro (P1 and P5), São Paulo (P3) and Bahia (P2 and P4) states. For each viral isolate in vitro characteristics such as replication rate, syncytium-inducing capacity and cell death were observed in lymphoblastoid (H9, CEM and peripheral blood mononuclear cells) as well as monocytoid (U937) cells. In addition, the evaluation of the restriction fragment length polymorphism of these isolates was also performed using a panel of endonucleases such as Hind III, Bgl II, Sac I, Pst I, Kpn I and Eco RI. One of the isolates (P1), showed the highest phenotypic and genotypic divergence, when compared to others. The results found suggest a HIV heterogeneity in Brazil similar to that already described in other regions of the world. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Subject | Brazilian HIV | pt_BR |
| Subject | Virulence | pt_BR |
| Subject | Restriction analysis | pt_BR |
| Subject | Viral diversity | pt_BR |
| DeCS | DNA Viral/análise | pt_BR |
| DeCS | Variação Genética | pt_BR |
| DeCS | HIV-1/genética | pt_BR |
| DeCS | Síndrome de Imunodeficiência | pt_BR |
| DeCS | Adquirida/microbiologia | pt_BR |
| DeCS | Brasil | pt_BR |
| DeCS | HIV-1/patogenicidade | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Polimorfismo Genético | pt_BR |
| DeCS | Polimorfismo de Fragmento de Restrição | pt_BR |
| DeCS | Mapeamento por Restrição | pt_BR |
| DeCS | Virulência | pt_BR |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
