| Author | Sant’Anna, Thaís B. | |
| Author | Araujo, Natalia M. | |
| Access date | 2023-02-19T14:08:09Z | |
| Available date | 2023-02-19T14:08:09Z | |
| Document date | 2022 | |
| Citation | SANT´ANNA, Thaís; ARAUJO, Natalia M. Adeno-associated virus infection and its impact in human health: an overview. Virology Journal, v. 19, 173, p. 1 - 13, 2022. | en_US |
| ISSN | 1743-422X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57092 | |
| Language | eng | en_US |
| Publisher | BMC | en_US |
| Rights | open access | |
| Subject in Portuguese | Vírus adeno-associado | en_US |
| Subject in Portuguese | Patogênese | en_US |
| Subject in Portuguese | Tumorigênese | en_US |
| Subject in Portuguese | Carcinoma hepatocelular | en_US |
| Subject in Portuguese | Distúrbios reprodutivos | en_US |
| Subject in Portuguese | AAV tipo selvagem | en_US |
| Subject in Portuguese | Terapia de genes | en_US |
| Subject in Portuguese | Saúde humana | en_US |
| Subject in Portuguese | Câncer cervical | en_US |
| Title | Adeno-associated virus infection and its impact in human health: an overview | en_US |
| Type | Article | |
| DOI | 10.1186/s12985-022-01900-4 | |
| Abstract | Discovered as a contaminant of adenovirus stocks in the 1960s, adeno-associated virus (AAV) is a mono-stranded
DNA virus that depends on helper factors to replicate. Even though AAV is endemic in the human population (35–
80%), it is remarkable that many issues concerning the natural infection by this virus remain unanswered. In this
study, we reflect on the main basic aspects of AAV biology and provide an overview of the studies exploring the
impact of AAV infection on human health, focusing on three major research areas including, (i) cervical and (ii) liver
cancer, and (iii) reproductive system disorders. Conflicting results have been obtained into the association of AAV
infection with the occurrence of adverse reproductive outcomes, such as placental complications, spontaneous
abortion, and fertility disorders, or with a protective role in HPV-related cervical carcinogenesis. Noteworthy, recent
reports have identified AAV insertional mutagenesis as a novel risk factor for the development of hepatocellular
carcinoma. This latest finding raises concern regarding the widespread usage of AAV vectors in liver-targeted gene
therapy. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Adeno-associated virus | en_US |
| Subject | Pathogenesis | en_US |
| Subject | Tumorigenesis | en_US |
| Subject | Hepatocellular carcinoma | en_US |
| Subject | Cervical cancer | en_US |
| Subject | Reproductive disorders | en_US |
| Subject | Wildtype AAV | en_US |
| Subject | Gene therapy | en_US |
| Subject | Human health | en_US |
