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ADENO-ASSOCIATED VIRUS INFECTION AND ITS IMPACT IN HUMAN HEALTH: AN OVERVIEW
Patogênese
Tumorigênese
Carcinoma hepatocelular
Distúrbios reprodutivos
AAV tipo selvagem
Terapia de genes
Saúde humana
Câncer cervical
Pathogenesis
Tumorigenesis
Hepatocellular carcinoma
Cervical cancer
Reproductive disorders
Wildtype AAV
Gene therapy
Human health
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Abstract
Discovered as a contaminant of adenovirus stocks in the 1960s, adeno-associated virus (AAV) is a mono-stranded
DNA virus that depends on helper factors to replicate. Even though AAV is endemic in the human population (35–
80%), it is remarkable that many issues concerning the natural infection by this virus remain unanswered. In this
study, we reflect on the main basic aspects of AAV biology and provide an overview of the studies exploring the
impact of AAV infection on human health, focusing on three major research areas including, (i) cervical and (ii) liver
cancer, and (iii) reproductive system disorders. Conflicting results have been obtained into the association of AAV
infection with the occurrence of adverse reproductive outcomes, such as placental complications, spontaneous
abortion, and fertility disorders, or with a protective role in HPV-related cervical carcinogenesis. Noteworthy, recent
reports have identified AAV insertional mutagenesis as a novel risk factor for the development of hepatocellular
carcinoma. This latest finding raises concern regarding the widespread usage of AAV vectors in liver-targeted gene
therapy.
Keywords in Portuguese
Vírus adeno-associadoPatogênese
Tumorigênese
Carcinoma hepatocelular
Distúrbios reprodutivos
AAV tipo selvagem
Terapia de genes
Saúde humana
Câncer cervical
Keywords
Adeno-associated virusPathogenesis
Tumorigenesis
Hepatocellular carcinoma
Cervical cancer
Reproductive disorders
Wildtype AAV
Gene therapy
Human health
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