Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5710
Title: Hyperplasia of elastic tissue in hepatic schistosomal fibrosis
Authors: Andrade, Zilton de Araújo
Freitas, Luiz Antonio Rodrigues de
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Elastic tissue hyperplasia, revealed by means of histological, immunocytochemical and ultra-structural methods, appeared as a prominent change in surgical liver biopsies taken from 61 patients with schistosomal periportal and septal fibrosis. Such hyperplasia was absent in experimental murine schistosomiasis, including mice with "pipe-stem" fibrosis. Displaced connective tissue cells in periportal areas, such as smooth muscle cells, more frequently observed in human material, could be the site of excessive elastin synthesis, and could explain the differences observed in human and experimental materials. Elastic tissue, sometimes represented by its microfibrillar components, also appeared to be more condensed in areas of matrix (collagen) degradation, suggesting a participation of this tissue in the remodelling of the extracellular matrix. By its rectratile properties elastic tissue hyperplasia in hepatic schistosomiasis can cause vascular narrowing and thus play a role in the pathogenesis of portal hypertension.
Keywords: Elastic tissue
Elastin
Schistosomiasis
Periportal fibrosis
Liver
DeCS: Tecido Elástico/patologia
Cirrose Hepática/patologia
Hepatopatias Parasitárias/patologia
Esquistossomose mansoni/patologia
Adolescente
Adulto
Feminino
Humanos
Hiperplasia/patologia
Fígado/ultraestrutura
Masculino
Meia-Idade
Issue Date: 1991
Citation: ANDRADE, Z. A.; FREITAS, L. A. Hyperplasia of elastic tissue in hepatic schistosomal fibrosis. Memórias do Instituto Oswaldo Cruz, v. 86, n. 4, p. 447-56, oct.-dec. 1991.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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