Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5712
Title: Experimental chemotherapy of Trypanosoma cruzi infection: persistence of parasite antigens and positive serology in parasitologically cured mice.
Authors: Andrade, Sonia Gumes
Freitas, Luiz Antonio Rodrigues de
Peyrol, S
Pimentel, Ariane R
Sadigursky, Moysés
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Institut Pasteur de Lyon. Centre de Microscopie Electronique. Research Assistant. Lyon, France
Universidade Federal da Bahia. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Mice infected with Trypanosoma cruzi, but parasitologically cured after specific chemotherapy, continued to exhibit positive indirect immunofluorescence serological tests 3-6 months after the therapy. Treatment of trypanosome antigens with monospecific antisera produced in rabbits, and examination by immunoelectron-microscopy following peroxidase labelling disclosed the presence of membrane deposits in cell processes in the spleens of the mice. Similar deposits were observed in the external membranes of T. cruzi amastigotes in the spleens of acutely infected mice, but not in normal control mice. No reaction occurred in tissues not previously treated with the monospecific anti-T. cruzi serum. Positive cells in treated and cured mice, as well as in the not cured or untreated control mice, were located in germinal centres of the splenic white pulp and presented long and branching cytoplasmic processes, which are indicative of dendritic cells of the lymphoid follicles of the spleen.
DeCS: Antígenos de Protozoários/sangue
Doença de Chagas/imunologia
Baço/química
Animais
Antígenos de Protozoários/química
Doença de Chagas/sangue
Doença de Chagas/quimioterapia
Camundongos
Microscopia Imunoeletrônica
Nifurtimox/uso terapêutico
Nitroimidazóis/uso terapêutico
Baço/patologia
Tripanossomicidas/uso terapêutico
Issue Date: 1991
Citation: ANDRADE, S.G. et al. Experimental chemotherapy of Trypanosoma cruzi infection: persistence of parasite antigens and positive serology in parasitologically cured mice. Bulletin of the World Health Organization, v. 69, n. 2, p. 191-7, 1991.
ISSN: 0042-9686
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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