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NEUROLOGICAL ASPECTS OF HIV-1/HTLV-1 AND HIV-1/HTLV-2 COINFECTION
HTLV
AIDS
HAM/TSP
Immunodeficiency
Myelopathy
Progression
T lymphocytes
Transmission
Coinfection
Araujo, Abelardo Q.-C. | Date Issued:
2020
Author
Affilliation
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil / The Federal University of Rio de Janeiro. Deolindo Couto Institute of Neurology. Rio de Janeiro, RJ, Brazil.
Abstract
Simultaneous infection by human immunodeficiency viruses (HIV) and human T-lymphotropic viruses (HTLV) are not uncommon since they have similar means of transmission and are simultaneously endemic in many populations. Besides causing severe immune dysfunction, these viruses are neuropathogenic and can cause neurological diseases through direct and indirect mechanisms. Many pieces of evidence at present show that coinfection may alter the natural history of general and, more specifically, neurological disorders through different mechanisms. In this review, we summarize the current evidence on the influence of coinfection on the progression and outcome of neurological complications of HTLV-1/2 and HIV-1.
Keywords
HIVHTLV
AIDS
HAM/TSP
Immunodeficiency
Myelopathy
Progression
T lymphocytes
Transmission
Coinfection
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