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GENOTYPE-SPECIFIC FEATURES REDUCE THE SUSCEPTIBILITY OF SOUTH AMERICAN YELLOW FEVER VIRUS STRAINS TO VACCINE-INDUCED ANTIBODIES
Haslwanter, Denise et al. | Date Issued: 2022
Author
Haslwanter, Denise
Lasso, Gorka
Vec, Anna Z.
Furtado, Nathália Dias
Raphael, Lidiane Menezes Souza
Tse, Alexandra L.
Sun, Yan
Stransky, Stephanie
Pedreño-Lopez, Núria
Correia, Carolina Argondizo
Bornholdt, Zachary A.
Sakharkar, Mrunal
Avelino-Silva, Vivian I.
Moyer, Crystal L.
Watkins, David I.
Kallas, Esper G.
Sidoli, Simone
Walker, Laura M.
Bonaldo, Myrna C.
Chandran, Kartik
Affilliation
Department of Microbiology and Immunology, Albert Einstein College of Medicine, The Bronx, NY 10461, USA.
Department of Microbiology and Immunology, Albert Einstein College of Medicine, The Bronx, NY 10461, USA.
Adimab, LLC, Lebanon, NH 03766, USA / Present address: Dyno Therapeutics, Cambridge, MA 02139, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Department of Microbiology and Immunology, Albert Einstein College of Medicine, The Bronx, NY 10461, USA.
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Department of Pathology, The George Washington University, Washington, DC 20037, USA / Present address: IrsiCaixa AIDS Research Institute, 08916 Badalona, Spain.
Universidade de São Paulo. Faculdade de Medicina. Laboratório de Imunologia Clínica e Alergia. São Paulo, SP, Brasil.
Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Adimab, LLC, Lebanon, NH 03766, USA.
Universidade de São Paulo. Faculdade de Medicina. Departamento de Molé stias Infecciosas e Parasitárias. São Paulo, SP, Brasil.
Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Department of Pathology, The George Washington University, Washington, DC 20037, USA.
Universidade de São Paulo. Faculdade de Medicina. Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil.
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Adimab, LLC, Lebanon, NH 03766, USA / Adagio Therapeutics Inc., Waltham, MA 02451, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Department of Microbiology and Immunology, Albert Einstein College of Medicine, The Bronx, NY 10461, USA / Lead contact.
Abstract
The resurgence of yellow fever in SouthAmerica has prompted vaccination against the etiologic agent, yellow fever virus (YFV). Current vaccines are based on a live-attenuated YF-17D virus derived from a virulent African isolate. The capacity of these vaccines to induce neutralizing antibodies against the vaccine strain is used as a surrogate for protection. However, the sensitivity of genetically distinct South American strains to vaccineinduced antibodies is unknown. We show that antiviral potency of the polyclonal antibody response in vaccinees is attenuated against an emergent Brazilian strain. This reduction was attributable to amino acid changes at two sites in central domain II of the glycoprotein E, including multiple changes at the domain I–domain II hinge, which are unique to and shared among most South American YFV strains. Our findings call for a reevaluation of current approaches to YFV immunological surveillance in South America and suggest approaches for updating vaccines.
Keywords in Portuguese
Características específicas do genótipo
Reduzem a suscetibilidade do amarelo sul-americano
Anticorpos induzidos por vacina
Cepas de vírus da febre Amarela
 
Keywords
Yellow fever virus
Genotype-specific features reduce
Susceptibility of South American
Yellow fever virus strains
Vaccine-induced antibodies
 
Publisher
Cell Press
Citation
HASLWANTER, Denise et al. Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies. Cell Host & Microbe. v. 30, p. 248-259, Feb. 2022.
DOI
10.1016/j.chom.2021.12.009
ISSN
1934-6069