Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5717
Title: Action of colchicine on hepatic schistosomal granuloma.
Authors: Andrade, Zilton de Araújo
Medeiros, Maria Vilma P
Carmo, Theomira Mauadie de Azevedo
Guerret, Sylviane Stocker
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Amorphous material and altered collagen fragments within dilated secretory vesicles and cisternae of fibroblast cytoplasm were the main ultrastructural changes seen in hepatic periovular granulomas formed in mice infected with Schistosoma mansoni and treated with colchicine. Despite promoting ultrastructural changes in the fibroblasts found in hepatic periovular granulomas, colchicine administration to infected mice did not significantly change the light microscopic appearance of the hepatic schistosomal lesions, did not diminish the amount of total hepatic collagen, and did not change the collagen isotypes in the granulomas, as observed after a comparative study with non-colchicine treated infected control mice. When administered to mice two weeks after curative treatment of schistosomiasis with praziquantel, colchicine did not seem to increase extracellular collagen degradation or to induce a more rapid resorption of hepatic periovular granulomas, although still promoting ultrastructural alterations in fibroblasts.
Keywords: Schistosoma mansoni
Fibrosis
Colchicine
Periovular granuloma
DeCS: Colchicina/uso terapêutico
Granuloma/quimioterapia
Hepatopatias Parasitárias/quimioterapia
Esquistossomose mansoni/quimioterapia
Animais
Colágeno/metabolismo
Feminino
Granuloma/patologia
Fígado/ultraestrutura
Hepatopatias Parasitárias/patologia
Masculino
Camundongos
Microscopia Eletrônica
Esquistossomose mansoni/patologia
Issue Date: 1990
Citation: ANDRADE, Z.A. et al. Action of colchicine on hepatic schistosomal granuloma. Memórias do Instituto Oswaldo Cruz, v. 85, n. 1, p. 79-85, jan.-mar. 1990.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Andrade ZA Action of colchicine on ....pdf605.71 kBAdobe PDFThumbnail
View/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.