Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5725
Title: Treatment of acute experimental schistosomiasis.
Authors: Andrade, Zilton de Araújo
Carmo, Theomira Mauadie de Azevedo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: A model of acute schistosomiasis of the mouse was used to observe whether curative treatment would be followed by an enhancement of the hepatic and splenic lesions, as a consequence of the massive destruction of worms and eggs within the portal system. Mice infected with 50 cercariae of Schistosoma mansoni were treated with both oxamniquine and praziquantel on the 50th day of infection and submitted to a sequential histologic examination from the 2nd to the 45th day after treatment. Although severe focal lesions due to dead and disintegrating worms were present in the livers of the treated animals, no aggravation of the general changes (reactive hepatitis and splenitis, or periovular granulomas) was seen in comparison with a control non-treated group. Of 50 animals treated during the acute phase of schistosomiasis only one died spontaneously, while 16 out of 30 infected controls died before the end of the experiment. The present investigation indicates that curative treatment during the acute phase of schistosomiasis does not enhance previous lesions at first and results in progressive disappearance of the lesions starting six days following chemotherapy.
Keywords: Acute schistosomiasis
Chemotherapy
Hepatic and splenic lesions
Schistosoma mansoni
DeCS: Hepatopatias Parasitárias/quimioterapia
Oxamniquine/uso terapêutico
Praziquantel/uso terapêutico
Esquistossomose/quimioterapia
Esplenopatias/quimioterapia
Doença Aguda
Animais
Feminino
Granuloma/parasitologia
Hepatopatias Parasitárias/patologia
Masculino
Camundongos
Esquistossomose/patologia
Esplenopatias/patologia
Issue Date: 1989
Citation: ANDRADE, Z. A.; AZEVEDO, T. M. de. Treatment of acute experimental schistosomiasis. Memórias do Instituto Oswaldo Cruz, v. 84, n. 4, p. 477-484, oct.-dez. 1989.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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