Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5725
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dc.contributor.authorAndrade, Zilton de Araújo
dc.contributor.authorCarmo, Theomira Mauadie de Azevedo
dc.date.accessioned2012-10-23T19:25:47Z
dc.date.available2012-10-23T19:25:47Z
dc.date.issued1989
dc.identifier.citationANDRADE, Zilton de Araújo; CARMO, Theomira Mauadie de Azevedo. Treatment of acute experimental schistosomiasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 84, n. 4, p. 477-484, Oct./Dec. 1989.
dc.identifier.issn0074-0276
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/5725
dc.language.isoeng
dc.rightsopen access
dc.titleTreatment of acute experimental schistosomiasis
dc.typeArticle
dc.identifier.doi10.1590/S0074-02761989000400004
dc.description.abstractenA model of acute schistosomiasis of the mouse was used to observe whether curative treatment would be followed by an enhancement of the hepatic and splenic lesions, as a consequence of the massive destruction of worms and eggs within the portal system. Mice infected with 50 cercariae of Schistosoma mansoni were treated with both oxamniquine and praziquantel on the 50th day of infection and submitted to a sequential histologic examination from the 2nd to the 45th day after treatment. Although severe focal lesions due to dead and disintegrating worms were present in the livers of the treated animals, no aggravation of the general changes (reactive hepatitis and splenitis, or periovular granulomas) was seen in comparison with a control non-treated group. Of 50 animals treated during the acute phase of schistosomiasis only one died spontaneously, while 16 out of 30 infected controls died before the end of the experiment. The present investigation indicates that curative treatment during the acute phase of schistosomiasis does not enhance previous lesions at first and results in progressive disappearance of the lesions starting six days following chemotherapy.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
dc.subject.enAcute schistosomiasis
dc.subject.enChemotherapy
dc.subject.enHepatic and splenic lesions
dc.subject.enSchistosoma mansoni
dc.subject.decsHepatopatias Parasitárias/quimioterapia
dc.subject.decsOxamniquine/uso terapêutico
dc.subject.decsPraziquantel/uso terapêutico
dc.subject.decsEsquistossomose/quimioterapia
dc.subject.decsEsplenopatias/quimioterapia
dc.subject.decsDoença Aguda
dc.subject.decsAnimais
dc.subject.decsFeminino
dc.subject.decsGranuloma/parasitologia
dc.subject.decsHepatopatias Parasitárias/patologia
dc.subject.decsMasculino
dc.subject.decsCamundongos
dc.subject.decsEsquistossomose/patologia
dc.subject.decsEsplenopatias/patologia
Appears in Collections:BA - IGM - Artigos de Periódicos

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