Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValue
dc.contributor.authorAndrade, Zilton de Araújo
dc.contributor.authorCarmo, Theomira Mauadie de Azevedo
dc.identifier.citationANDRADE, Zilton de Araújo; CARMO, Theomira Mauadie de Azevedo. Treatment of acute experimental schistosomiasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 84, n. 4, p. 477-484, Oct./Dec. 1989.
dc.rightsopen access
dc.titleTreatment of acute experimental schistosomiasis
dc.description.abstractenA model of acute schistosomiasis of the mouse was used to observe whether curative treatment would be followed by an enhancement of the hepatic and splenic lesions, as a consequence of the massive destruction of worms and eggs within the portal system. Mice infected with 50 cercariae of Schistosoma mansoni were treated with both oxamniquine and praziquantel on the 50th day of infection and submitted to a sequential histologic examination from the 2nd to the 45th day after treatment. Although severe focal lesions due to dead and disintegrating worms were present in the livers of the treated animals, no aggravation of the general changes (reactive hepatitis and splenitis, or periovular granulomas) was seen in comparison with a control non-treated group. Of 50 animals treated during the acute phase of schistosomiasis only one died spontaneously, while 16 out of 30 infected controls died before the end of the experiment. The present investigation indicates that curative treatment during the acute phase of schistosomiasis does not enhance previous lesions at first and results in progressive disappearance of the lesions starting six days following chemotherapy.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
dc.subject.enAcute schistosomiasis
dc.subject.enHepatic and splenic lesions
dc.subject.enSchistosoma mansoni
dc.subject.decsHepatopatias Parasitárias/quimioterapia
dc.subject.decsOxamniquine/uso terapêutico
dc.subject.decsPraziquantel/uso terapêutico
dc.subject.decsDoença Aguda
dc.subject.decsHepatopatias Parasitárias/patologia
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Andrade Za Treatment of acute experimental....pdf484.29 kBAdobe PDFThumbnail

FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.