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ANTILESHIMANIA, ANTI-TRYPANOSOMA CRUZI AND ANTIMICROBIAL ACTIVITIES OF SCANDENIN AND 4’-O-METHYLDERRONE FROM DEGUELIA COSTATA
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Scandenin and 4’-O-methylderrone were isolated from the ethanolextract of the roots and dichloromethane extract of the leaves ofDeguelia costata(Benth.) A.M.G. Azevedo & R.A. Camargo, respect-ively. These compounds and their extracts had their antiprotozoal,antibacterial, antifungal, and cytotoxic activities tested. All sam-ples were active for amastigotes of theT. cruzi, with EC50valuesvarying from 34.5 to 9.8mgmL 1. The 4’-O-methylderrone andscandenin showed better leishmanicidal action against the pro-mastigote ofL. amazonensis, with EC50of 43.3 and 45.9mgmL 1,respectively, when compared to their extracts. All extracts andscandenin showed activities againstStaphylococcussp,Bacillussp,andCandidasp. The compounds did not show cytotoxicity on ratmacrophages. As confirmed by spectroscopic analyses, theextracts are rich in phenolics, mainly isoflavonoids. The study ofD. costatais a promising strategy for discovering isoflavones and4-hydroxy-3-phenylcoumarins with antiprotozoal, antibacterial,and antifungal activities.
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