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Title: Pathogenesis of pipe-stem fibrosis of the liver (experimental observation on murine schistosomiasis).
Authors: Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Mice infected with 30 cercariae of Schistosoma mansoni developed portal and septal fibrosis due to the massive and concentrated deposition of eggs in the periportal areas which occurred following the 16th week after infection. The lesion resembled pipe-stem fibrosis seen in human hepatosplenic schistosomiasis in the following characters: portal fibrosis interconnecting portal spaces as well as portal spaces and central canals; portal inflammation; periovular granulomas; vascular obstruction and telangiectasia. The liver parenchyma maintained its normal architecture. Vascular injection techniques with Indian ink and vinylite revealed that the portal system developed numerous dilated collateral venules coming from the large and medium-sized portal branches, about 10 weeks after schistosome infection. The lodging of schistosome eggs into these collaterals resulted in granulomatous inflammation and fibrosis along all the portal tracts, thus forming the pipe-stem lesion. Although not readily demonstrable grossly, the pipe-stem fibrosis of murine schistosomiasis has many similarities with the human lesion and can be considered to have the same basic pathogenesis.
Keywords: Schistosomiasis
Pipe-stem fibrosis
DeCS: Cirrose Hepática Experimental/etiologia
Hepatopatias Parasitárias/etiologia
Sistema Porta
Esquistossomose mansoni/complicações
Cirrose Hepática Experimental/patologia
Hepatopatias Parasitárias/patologia
Esquistossomose mansoni/patologia
Doenças Vasculares/parasitologia
Doenças Vasculares/patologia
Issue Date: 1987
Citation: ANDRADE, Z.A. Pathogenesis of pipe-stem fibrosis of the liver (experimental observation on murine schistosomiasis). Memórias do Instituto Oswaldo Cruz, v. 82, n. 3, p. 325-34, jul.-sep. 1987.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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