Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5732
Title: A contribution to the study of acute schistosomiasis (an experimental trial).
Authors: Andrade, Zilton de Araújo
Carmo, Theomira Mauadie de Azevedo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: In an attempt to establish an experimental model of acute schistosomiasis, sequential histological changes were investigated in the skin, lung, liver and spleen of mice infected with 30 or 100 cercariae of Schistosoma mansoni according to four sets of experiments: single infection, repeated infections, unisexual infection and infection in mice born from infected mothers. Animals were killed every other day from exposure up to 50 days after infection. Only mild, isolated, focal inflammatory changes were found before the appearance of mature eggs in the liver, even when repeated infections were made. Severe changes of reactive hepatitis and splenitis appeared suddenly when the first mature eggs were deposited, around the 37th to 42nd day after infection. The mature eggs induced lytic and coagulative necrosis of hepatocytes around them which was soon followed by dense infiltration of eosinophils. So, mature egg-induced lesions appeared as the major factors in the pathogenesis of acute schistosomiasis in mice. Mice born from infected mothers were apparently able to rapidly modulate the egg-lesions, forming early fibrotic granulomas. The murine model of acute schistosomiasis appeared adequate for the study of pathology and pathogenesis of acute schistosomiasis.
Keywords: Acute schistosomiasis
Pathogenesis
Experimental schistosomiasis
DeCS: Esquistossomose mansoni/parasitologia
Doença Aguda
Animais
Modelos Animais de Doenças
Feminino
Hepatopatias Parasitárias/patologia
Pneumopatias Parasitárias/patologia
Masculino
Camundongos
Esquistossomose mansoni/patologia
Dermatopatias Infecciosas/patologia
Esplenopatias/patologia
Issue Date: 1987
Citation: ANDRADE, Z.A.; AZEVEDO, T.M. de. A contribution to the study of acute schistosomiasis (an experimental trial). Memórias do Instituto Oswaldo Cruz, v. 82, n. 3, p. 311-7, jul.-sep. 1987.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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