Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5732
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dc.contributor.authorAndrade, Zilton de Araújo
dc.contributor.authorCarmo, Theomira Mauadie de Azevedo
dc.date.accessioned2012-10-23T21:24:56Z
dc.date.available2012-10-23T21:24:56Z
dc.date.issued1987
dc.identifier.citationANDRADE, Z.A.; AZEVEDO, T.M. de. A contribution to the study of acute schistosomiasis (an experimental trial). Memórias do Instituto Oswaldo Cruz, v. 82, n. 3, p. 311-7, jul.-sep. 1987.
dc.identifier.issn0074-0276
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/5732
dc.language.isoeng
dc.rightsopen access
dc.titleA contribution to the study of acute schistosomiasis (an experimental trial).
dc.typeArticle
dc.description.abstractenIn an attempt to establish an experimental model of acute schistosomiasis, sequential histological changes were investigated in the skin, lung, liver and spleen of mice infected with 30 or 100 cercariae of Schistosoma mansoni according to four sets of experiments: single infection, repeated infections, unisexual infection and infection in mice born from infected mothers. Animals were killed every other day from exposure up to 50 days after infection. Only mild, isolated, focal inflammatory changes were found before the appearance of mature eggs in the liver, even when repeated infections were made. Severe changes of reactive hepatitis and splenitis appeared suddenly when the first mature eggs were deposited, around the 37th to 42nd day after infection. The mature eggs induced lytic and coagulative necrosis of hepatocytes around them which was soon followed by dense infiltration of eosinophils. So, mature egg-induced lesions appeared as the major factors in the pathogenesis of acute schistosomiasis in mice. Mice born from infected mothers were apparently able to rapidly modulate the egg-lesions, forming early fibrotic granulomas. The murine model of acute schistosomiasis appeared adequate for the study of pathology and pathogenesis of acute schistosomiasis.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.subject.enAcute schistosomiasis
dc.subject.enPathogenesis
dc.subject.enExperimental schistosomiasis
dc.subject.decsEsquistossomose mansoni/parasitologia
dc.subject.decsDoença Aguda
dc.subject.decsAnimais
dc.subject.decsModelos Animais de Doenças
dc.subject.decsFeminino
dc.subject.decsHepatopatias Parasitárias/patologia
dc.subject.decsPneumopatias Parasitárias/patologia
dc.subject.decsMasculino
dc.subject.decsCamundongos
dc.subject.decsEsquistossomose mansoni/patologia
dc.subject.decsDermatopatias Infecciosas/patologia
dc.subject.decsEsplenopatias/patologia
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