Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5738
Title: The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations.
Authors: Andrade, Sonia Gumes
Sadigursky, Moysés
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Chronic focal and diffuse myocarditis with interstitial fibrosis developed in Swiss outbred mice and in the inbred AKR and A/J strains of mice which were chronically infected with several Trypanosoma cruzi strains belonging to three biological types (Type I, II and III). High incidence of electrocardiographic changes with predominance of intraventricular conduction disturbances, 1st. and 2nd. degree AV block, arrhythmias, comparable with those found in human Chagas' disease, were also present. Morphological study of the conduction tissue of the heart revealed inflammatory and fibrotic changes. The presence of inflammation in the inter-atrial septum almost always coincided with the inflammatory involvement of the ventricular conduction system. Focal inflammation was associated with vacuolization and focal necrosis of the specific fibers. Most of the lesions were seen affecting the His bundle (76.3% of the cases), the right bundle branch (73.3%), AV node (43.9%) and left bundle branch (37.5%). Correlation between morphological changes in the conduction tissue and electrocardiographic alteration occurred in 53.0 to 62.5% of the cases, according to the experimental groups.
Keywords: Conduction system of the heart
Trypanosoma cruzi
Chronic myocarditis
Chronic T. cruzi
Infection in mice
Electrocardiogram in mice
DeCS: Cardiomiopatia Chagásica/fisiopatologia
Eletrocardiografia
Sistema de Condução Cardíaco/fisiopatologia
Miocárdio/patologia
Animais
Bloqueio Cardíaco/patologia
Camundongos
Camundongos Endogâmicos A
Camundongos Endogâmicos AKR
Issue Date: 1987
Citation: ANDRADE, S.G.; SADIGURSKY, M. The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations. Memórias do Instituto Oswaldo Cruz, v. 82, n. 1, p. 59-66, jan.-mar. 1987.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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