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2030
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REFERENCE VALUES FOR THE TRIGLYCERIDE TO HIGH-DENSITY LIPOPROTEIN RATIO AND ITS ASSOCIATION WITH CARDIOMETABOLIC DISEASES IN A MIXED ADULT POPULATION: THE ELSA-BRASIL STUDY
Lelis, Deborah de Farias et al. | Date Issued: 2021
Author
Lelis, Deborah de Farias
Calzavara, João Vitor S.
Santos, Raul D.
Sposito, Andrei C.
Griep, Rosane Harter
Barreto, Sandhi Maria
Molina, Maria del Carmen B.
Schmidt, Maria Inês
Duncan, Bruce B.
Bensenor, Isabella
Lotufo, Paulo Andrade
Mill, José Geraldo
Baldo, Marcelo Perim
Affilliation
Department of Pathophysiology, Montes Claros State University (UNIMONTES), Montes Claros, MG, Brazil.
Department of Pathophysiology, Montes Claros State University (UNIMONTES), Montes Claros, MG, Brazil.
Lipid Clinic Heart Institute (Incor) University of São Paulo Medical School Hospital, São Paulo, Brazil.
Cardiology Division, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, SP, BraziL.
Laboratory of Health and Environment Education, Oswaldo Cruz Institute, Rio de Janeiro, RJ, Brazil.
Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Post Graduate Programme in Public Health, Federal University of Espírito Santo, Vitória, ES, Brazil.
School of Medicine and Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
School of Medicine and Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Center for Clinical and Epidemiologic Research, University of São Paulo, São Paulo, SP, Brazil.
Center for Clinical and Epidemiologic Research, University of São Paulo, São Paulo, SP, Brazil.
Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, Brazil.
Department of Pathophysiology, Montes Claros State University (UNIMONTES), Montes Claros, MG, Brazil.
Abstract
BACKGROUND: Among several lipid ratios available, the triglyceride/HDL-cholesterol (TG/HDL-C) may detect individuals at risk of cardiometabolic diseases. However, its reference values for different ethnicities are not well established. OBJECTIVE: To define sex- and ethnicity-specific reference values for TG/HDL-C ratio in a large sample of healthy multiethnic adults and test its association with cardiometabolic conditions. METHODS: An apparently healthy sample ( n = 2,472), aged 35–74, free of major cardiovascular risk factors, was used to generate the reference values for the TG/HDL-C. Exclusion criteria were diabetes, elevated blood pressure, obesity, hypercholesterolemia, severe hypertriglyceridemia, and smoking his- tory. Cut-offs based on the reference values were tested in the whole ELSA Brasil study ( n = 13,245), stratified by sex and ethnicity, to identify cardiometabolic conditions.
Keywords in Portuguese
Triglicerídeos
Colesterol de lipoproteína de alta densidade
Relação TG/HDL-C
Valores de referência
Doenças cardiometabólicas
 
Keywords
Triglycerides
High-density lipoprotein cholesterol
TG/HDL-C ratio
Reference values
Cardiometabolic diseases
 
Publisher
Elsevier Inc.
Citation
LELIS, Deborah de Farias et al. Reference values for the triglyceride to high-density lipoprotein ratio and its association with cardiometabolic diseases in a mixed adult population: The ELSA-Brasil study. Journal of Clinical Lipidology, 000, p. 1 - 13, 2021.
DOI
10.1016/j.jacl.2021.07.005
ISSN
1933-2874